Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine

Figure 8

Cannabidiol (CBD; 30 mg/Kg) prevented liver inflammation and seizure due to cocaine intake. (a) Liver histology showing that while CBD-treated mice have a normal liver architecture, cocaine-treated mice (75 mg/Kg) had extensive areas which were suggestive of malperfusion caused by necrosis. (b) Reduced necrotic area, histological score, and neutrophil infiltration confirmed the anti-inflammatory and protective effects of CBD during cocaine-induced hepatotoxicity. However, inhibition of anandamide hydrolysis by URB had no detectable effect on liver parameters. (c) Despite lack of effect on liver injury, both CBD and URB inhibited cocaine-induced seizure, increasing latency and reducing seizure duration. Statistical significance in comparison to controls () and in comparison to vehicle-treated group. A 10x objective was used during imaging. One-way ANOVA with Tukey’s post hoc test. Data are expressed as ( mice/treatment).

(a)

(b)

(c)