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Mediators of Inflammation
Volume 2015, Article ID 531518, 10 pages
http://dx.doi.org/10.1155/2015/531518
Review Article

Inflammatory Cytokines: Potential Biomarkers of Immunologic Dysfunction in Autism Spectrum Disorders

1Department of Children’s Health, Hunan Children’s Hospital, Hunan, China
2Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, NY 10314, USA

Received 8 October 2014; Accepted 2 January 2015

Academic Editor: Elaine Hatanaka

Copyright © 2015 Ningan Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [53 citations]

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  • J Verduijn, Y Milaneschi, R A Schoevers, A M van Hemert, A T F Beekman, and B W J H Penninx, “Pathophysiology of major depressive disorder: mechanisms involved in etiology are not associated with clinical progression.,” Translational psychiatry, vol. 5, 2015. View at Publisher · View at Google Scholar
  • Theoharides, Tsilioni, Taliou, and Francis, “Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6,” Translational Psychiatry, vol. 5, no. 9, 2015. View at Publisher · View at Google Scholar
  • Carmem Gottfried, Victorio Bambini-Junior, Fiona Francis, Rudimar Riesgo, and Wilson Savino, “The Impact of Neuroimmune Alterations in Autism Spectrum Disorder,” Frontiers in Psychiatry, vol. 6, 2015. View at Publisher · View at Google Scholar
  • Marco Atzori, and Manuel Mejia, “Nicotine for psychiatric disease: From nuisance to novel treatment?,” Future Medicinal Chemistry, vol. 7, no. 10, pp. 1217–1220, 2015. View at Publisher · View at Google Scholar
  • Daisuke Ibi, and Kiyofumi Yamada, “Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation,” International Journal of Molecular Sciences, vol. 16, no. 12, pp. 28218–28229, 2015. View at Publisher · View at Google Scholar
  • Brandy A. Briones, Maya Opendak, Samuel S.-H. Wang, Elizabeth Gould, Elise C. Cope, Adam T. Brockett, Susana Martinez, and Pierre-Antoine Vigneron, “Immature neurons and radial glia, but not astrocytes or microglia, are altered in adult Cntnap2 and Shank3 mice, models of autism,” eNeuro, vol. 3, no. 5, 2016. View at Publisher · View at Google Scholar
  • Yidong Shen, Jianjun Oua, Mengmeng Liu, Lijuan Shi, Yamin Li, Lu Xiao, Huixi Dong, Fengyu Zhang, Kun Xia, and Jingping Zhao, “Altered plasma levels of chemokines in autism and their association with social behaviors,” Psychiatry Research, 2016. View at Publisher · View at Google Scholar
  • Helen E. Vuong, and Elaine Y. Hsiao, “Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder,” Biological Psychiatry, 2016. View at Publisher · View at Google Scholar
  • Cui-Yu Li, Yi-Han Meng, Zhe-Ming Ying, Nan Xu, Dong Hao, Ming-Zhe Gao, Wen-Jie Zhang, Liang Xu, Yu-Cong Gao, and Xi-Xiang Ying, “ Three Novel Alkaloids from Portulaca oleracea L. and Their Anti-inflammatory Effects ,” Journal of Agricultural and Food Chemistry, 2016. View at Publisher · View at Google Scholar
  • Chaitrali Saha, Mrinmoy Das, Emmanuel Stephen-Victor, Alain Friboulet, Jagadeesh Bayry, and Srini Kaveri, “Differential Effects of Viscum album Preparations on the Maturation and Activation of Human Dendritic Cells and CD4+ T Cell Responses,” Molecules, vol. 21, no. 7, pp. 912, 2016. View at Publisher · View at Google Scholar
  • Peter P. Sordillo, Laura A. Sordillo, and Lawrence Helson, “Bifunctional role of pro-inflammatory cytokines after traumatic brain injury,” Brain Injury, pp. 1–11, 2016. View at Publisher · View at Google Scholar
  • Zhi-Jian Wang, Xiao-Hong Liu, Li Jin, De-Yong Pu, Jing Huang, and Yao-Guang Zhang, “Transcriptome profiling analysis of rare minnow (Gobiocypris rarus) gills after waterborne cadmium exposure,” Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2016. View at Publisher · View at Google Scholar
  • Akhtar Rasool Asif, Sumayyah Qadri, Nabeel Ijaz, Ruheena Javed, Abdur Rahman Ansari, Muhammd Awais, Muhammad Younus, Hasan Riaz, and Xiaoyong Du, “Genetic signature of strong recent positive selection at interleukin-32 gene in goat,” Asian-Australasian Journal of Animal Sciences, vol. 30, no. 7, pp. 912–919, 2016. View at Publisher · View at Google Scholar
  • Wenjie Zhang, Yu Zheng, Yihan Meng, Zheming Ying, Zheng Xiang, Dong Hao, Yucong Gao, and Xixiang Ying, “The anti-inflammation and pharmacokinetics of a novel alkaloid from Portulaca oleracea L.,” Journal of Pharmacy and Pharmacology, vol. 68, no. 3, pp. 397–405, 2016. View at Publisher · View at Google Scholar
  • Jill Hutton, “Does Rubella Cause Autism: A 2015 Reappraisal?,” Frontiers in Human Neuroscience, vol. 10, 2016. View at Publisher · View at Google Scholar
  • Martha Inga Jácome, Lilia Morales Chacòn, Hector Vera Cuesta, Carlos Maragoto Rizo, Mabel Whilby Santiesteban, Lesyanis Ramos Hernandez, Elena Noris García, Maria González Fraguela, Caridad Fernandez Verdecia, Yamilé Vegas Hurtado, Dario Siniscalco, Carlos Gonçalves, and Maria Robinson-Agramonte, “Peripheral Inflammatory Markers Contributing to Comorbidities in Autism,” Behavioral Sciences, vol. 6, no. 4, pp. 29, 2016. View at Publisher · View at Google Scholar
  • Vesna Bryn, Ola H. Skjeldal, Hans Christian Dalsbotten Aass, Jørn Isaksen, Ola Didrik Saugstad, and Heidi Ormstad, “Cytokine Profile in Autism Spectrum Disorders in Children,” Journal of Molecular Neuroscience, vol. 61, no. 1, 2016. View at Publisher · View at Google Scholar
  • Geir Bjørklund, Khaled Saad, Salvatore Chirumbolo, David A. Geier, Janet K. Kern, Mark R. Geier, and Mauricio A. Urbina, “Immune dysfunction and neuroinflammation in autism spectrum disorder,” Acta Neurobiologiae Experimentalis, vol. 76, no. 4, pp. 257–268, 2016. View at Publisher · View at Google Scholar
  • Joana Prata, Susana G. Santos, Maria Inês Almeida, Rui Coelho, and Mário A. Barbosa, “Bridging Autism Spectrum Disorders and Schizophrenia through inflammation and biomarkers - pre-clinical and clinical investigations,” Journal of Neuroinflammation, vol. 14, no. 1, 2017. View at Publisher · View at Google Scholar
  • David A. Geier, Janet K. Kern, and Mark R. Geier, “Increased risk for an atypical autism diagnosis following Thimerosal-containing vaccine exposure in the United States: A prospective longitudinal case-control study in the Vaccine Safety Datalink,” Journal of Trace Elements in Medicine and Biology, vol. 42, pp. 18–24, 2017. View at Publisher · View at Google Scholar
  • Anna Brigida, Stephen Schultz, Mariana Cascone, Nicola Antonucci, and Dario Siniscalco, “Endocannabinod Signal Dysregulation in Autism Spectrum Disorders: A Correlation Link between Inflammatory State and Neuro-Immune Alterations,” International Journal of Molecular Sciences, vol. 18, no. 7, pp. 1425, 2017. View at Publisher · View at Google Scholar
  • Syed Shahid Habib, Khalid Al-Regaiey, Shahid Bashir, and Muhammad Iqbal, “Role of endocannabinoids on neuroinflammation in autism spectrum disorder prevention,” Journal of Clinical and Diagnostic Research, vol. 11, no. 6, pp. CE01–CE03, 2017. View at Publisher · View at Google Scholar
  • Adam J. Guastella, Anne Masi, Nicholas Glozier, and Russell Dale, “The Immune System, Cytokines, and Biomarkers in Autism Spectrum Disorder,” Neuroscience Bulletin, vol. 33, no. 2, pp. 194–204, 2017. View at Publisher · View at Google Scholar
  • Jucélia Jeremias Fortunato, Naiana da Rosa, Ana Olívia Martins Laurentino, Marina Goulart, Camila Michalak, Lidiane Pinto Borges, Evandro da Cruz Cittadin Soares, Patricia Alves Reis, Hugo Caire de Castro Faria Neto, and Fabrícia Petronilho, “Effects of ω-3 fatty acids on stereotypical behavior and social interactions in Wistar rats prenatally exposed to lipopolysaccarides,” Nutrition, vol. 35, pp. 119–127, 2017. View at Publisher · View at Google Scholar
  • Feiyong Jia, Ling Shan, Bing Wang, Honghua Li, Chunyue Miao, Zhida Xu, Ching-Po Lin, and Khaled Saad, “Bench to Bedside Review: Possible Role of Vitamin D in Autism Spectrum Disorder,” Psychiatry Research, 2017. View at Publisher · View at Google Scholar
  • Richard E. Frye, Bistra Nankova, Sudeepa Bhattacharyya, Shannon Rose, Sirish C. Bennuri, and Derrick F. MacFabe, “Modulation of Immunological Pathways in Autistic and Neurotypical Lymphoblastoid Cell Lines by the Enteric Microbiome Metabolite Propionic Acid,” Frontiers in Immunology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Najmeh Pirzadroozbahani, Seyyed Amir Yasin Ahmadi, Hamidreza Hekmat, Golnaz Atri Roozbahani, and Farhad Shahsavar, “Autism and KIR genes of the human genome: A brief meta-analysis,” Egyptian Journal of Medical Human Genetics, 2017. View at Publisher · View at Google Scholar
  • Natalia Yanguas-Casás, Andrea Crespo-Castrillo, Maria L. de Ceballos, Julie A. Chowen, Iñigo Azcoitia, Maria Angeles Arevalo, and Luis M. Garcia-Segura, “Sex differences in the phagocytic and migratory activity of microglia and their impairment by palmitic acid,” Glia, 2017. View at Publisher · View at Google Scholar
  • Chengyun Feng, Youjiao Chen, Jintao Pan, Aochu Yang, Li Niu, Jie Min, Xianling Meng, Liping Liao, Kaoyuan Zhang, and Liming Shen, “Redox proteomic identification of carbonylated proteins in autism plasma: insight into oxidative stress and its related biomarkers in autism,” Clinical Proteomics, vol. 14, no. 1, 2017. View at Publisher · View at Google Scholar
  • Yvonne M. Y. Han, Winnie K. Y. Cheung, Chun Kwok Wong, Sophia L. Sze, Timmy W. S. Cheng, Michael K. Yeung, and Agnes S. Chan, “Distinct Cytokine and Chemokine Profiles in Autism Spectrum Disorders,” Frontiers in Immunology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Hua Li, Hua Zhu, Jiang Xie, Li Huang, Xiaohong Li, Yongmei Zhou, Tianying Pan, Keith M. Kendrick, and Wenming Xu, “Immunological cytokine profiling identifies TNF-α as a key molecule dysregulated in autistic children,” Oncotarget, vol. 8, no. 47, pp. 82390–82398, 2017. View at Publisher · View at Google Scholar
  • Yin-Hua Cheng, Ying-Chi Lin, Sian-De Liu, Chia-Chi Wang, Ih-Sheng Chen, and Jih-Heng Li, “Immunomodulatory Effects of Taiwanese Neolitsea Species on Th1 and Th2 Functionality,” Journal of Immunology Research, vol. 2017, 2017. View at Publisher · View at Google Scholar
  • Ramkripa Raghavan, Barry Zuckerman, Xiumei Hong, Guoying Wang, Yuelong Ji, David Paige, Jessica DiBari, Cuilin Zhang, M. Daniele Fallin, and Xiaobin Wang, “Fetal and Infancy Growth Pattern, Cord and Early Childhood Plasma Leptin, and Development of Autism Spectrum Disorder in the Boston Birth Cohort,” Autism Research, 2018. View at Publisher · View at Google Scholar
  • Mohammad Mahdi Eftekharian, Soudeh Ghafouri-Fard, Rezvan Noroozi, Mir Davood Omrani, Shahram Arsang-jang, Maziar Ganji, Vajiheh Gharzi, Hanieh Noroozi, Alireza Komaki, Mehrdokht Mazdeh, and Mohammad Taheri, “Cytokine profile in autistic patients,” Cytokine, vol. 108, pp. 120–126, 2018. View at Publisher · View at Google Scholar
  • Shathiswaran N. Andy, Vijayapandi Pandy, Zazali Alias, and Habsah Abdul Kadir, “Deoxyelephantopin ameliorates lipopolysaccharides (LPS)-induced memory impairments in rats: Evidence for its anti-neuroinflammatory properties,” Life Sciences, vol. 206, pp. 45–60, 2018. View at Publisher · View at Google Scholar
  • Guifeng Xu, Linda G. Snetselaar, Jin Jing, Buyun Liu, Lane Strathearn, and Wei Bao, “Association of Food Allergy and Other Allergic Conditions With Autism Spectrum Disorder in Children,” JAMA Network Open, vol. 1, no. 2, pp. e180279, 2018. View at Publisher · View at Google Scholar
  • Dario Siniscalco, Stephen Schultz, Anna Brigida, and Nicola Antonucci, “Inflammation and Neuro-Immune Dysregulations in Autism Spectrum Disorders,” Pharmaceuticals, vol. 11, no. 2, pp. 56, 2018. View at Publisher · View at Google Scholar
  • Omar Bagasra, and Cherilyn Heggenpp. 1–302, 2018. View at Publisher · View at Google Scholar
  • Omar Bagasra, Cherilyn Heggen, and Muhammad I. Hossain, “Vaccines and Autism,” Autism and Environmental Factors, pp. 261–286, 2018. View at Publisher · View at Google Scholar
  • Atiqah Azhari, Farouq Azizan, and Gianluca Esposito, “A systematic review of gut-immune-brain mechanisms in Autism Spectrum Disorder,” Developmental Psychobiology, 2018. View at Publisher · View at Google Scholar
  • Geir Bjørklund, Nagwa A. Meguid, Afaf El-Ansary, Mona A. El-Bana, Maryam Dadar, Jan Aaseth, Maha Hemimi, Joško Osredkar, and Salvatore Chirumbolo, “Diagnostic and Severity-Tracking Biomarkers for Autism Spectrum Disorder,” Journal of Molecular Neuroscience, 2018. View at Publisher · View at Google Scholar
  • Chengyun Feng, Jian Zhai, Liming Shen, Kaoyuan Zhang, Youjiao Chen, Shuiming Li, Javed Iqbal, Liping Liao, and Yuxi Zhao, “iTRAQ-Based Proteomic Analysis Reveals Protein Profile in Plasma from Children with Autism,” Proteomics - Clinical Applications, 2018. View at Publisher · View at Google Scholar
  • Sheikh F. Ahmad, Laila Y. AL-Ayadhi, Sabry M. Attia, Mushtaq A. Ansari, Ahmed Nadeem, and Saleh A. Bakheet, “Elevated IL-16 expression is associated with development of immune dysfunction in children with autism,” Psychopharmacology, 2018. View at Publisher · View at Google Scholar
  • Heidi Ormstad, Michael Maes, Vesna Bryn, Ola Didrik Saugstad, and Ola Skjeldal, “Role of the immune system in autism spectrum disorders (ASD),” CNS and Neurological Disorders - Drug Targets, vol. 17, no. 7, pp. 489–495, 2018. View at Publisher · View at Google Scholar
  • María Andrea Castillo, Kendy Eduardo Urdaneta, Neomar Semprún-Hernández, Anna Lisa Brigida, Nicola Antonucci, Stephen Schultz, and Dario Siniscalco, “Speech-Stimulating Substances in Autism Spectrum Disorders,” Behavioral Sciences, vol. 9, no. 6, pp. 60, 2019. View at Publisher · View at Google Scholar
  • Roohi Mirza, and Bhupesh Sharma, “Beneficial effects of pioglitazone, a selective peroxisome proliferator-activated receptor-γ agonist in prenatal Valproic acid-induced behavioral and biochemical autistic like features in Wistar rats,” International Journal of Developmental Neuroscience, 2019. View at Publisher · View at Google Scholar
  • Sheikh F. Ahmad, Mushtaq A. Ansari, Ahmed Nadeem, Saleh A. Bakheet, Moureq R. Alotaibi, Abdullah F. Alasmari, Musaad A. Alshammari, Haneen A. Al-Mazroua, and Sabry M. Attia, “DAPTA, a C-C chemokine receptor 5 (CCR5) antagonist attenuates immune aberrations by downregulating Th9/Th17 immune responses in BTBR T+ Itpr3tf/J mice,” European Journal of Pharmacology, vol. 846, pp. 100–108, 2019. View at Publisher · View at Google Scholar
  • Yasunori Yamashita, Manabu Makinodan, Michihiro Toritsuka, Takahira Yamauchi, Daisuke Ikawa, Sohei Kimoto, Takashi Komori, Ryohei Takada, Yoshinori Kayashima, Kaori Hamano-Iwasa, Masatsugu Tsujii, Hideo Matsuzaki, and Toshifumi Kishimoto, “Anti-inflammatory Effect of Ghrelin in Lymphoblastoid Cell Lines From Children With Autism Spectrum Disorder,” Frontiers in Psychiatry, vol. 10, 2019. View at Publisher · View at Google Scholar
  • Liming Shen, Chengyun Feng, Kaoyuan Zhang, Youjiao Chen, Yan Gao, Junyan Ke, Xinqian Chen, Jing Lin, Cuihua Li, Javed Iqbal, Yuxi Zhao, and Weibin Wang, “Proteomics Study of Peripheral Blood Mononuclear Cells (PBMCs) in Autistic Children,” Frontiers in Cellular Neuroscience, vol. 13, 2019. View at Publisher · View at Google Scholar
  • Roohi Mirza, and Bhupesh Sharma, “Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats,” Brain Research Bulletin, 2019. View at Publisher · View at Google Scholar
  • Shahram Barfi, Chimeh Narges, Hamid Reza Pouretemad, Vahdat Poortahmasebi, Mehdi Norouzi, Mohammad Farahmand, Yousef Yahyapour, Saeid Ghorbani, Leila Ghalichi, Haleh Ofoghi, and Seyed Mohammad Jazayeri, “Measurement of serum hepatitis B surface antibody levels in Iranian autistic children and evaluation of immunological memory after booster dose injection in comparison with controls,” Journal of Medical Virology, vol. 91, no. 7, pp. 1272–1278, 2019. View at Publisher · View at Google Scholar
  • Ryohei Furumai, Kota Tamada, Xiaoxi Liu, and Toru Takumi, “UBE3A regulates the transcription of IRF, an antiviral immunity,” Human Molecular Genetics, 2019. View at Publisher · View at Google Scholar
  • Hirofumi Kashii, Yoko Hagino, Miho Tanaka, Yasumasa Nishito, Yukio Takamatsu, Shigeo Uchino, Hiroko Kotajima-Murakami, Kazutaka Ikeda, Toshiyuki Kobayashi, and Atsushi Sato, “Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero,” Molecular Brain, vol. 12, no. 1, 2019. View at Publisher · View at Google Scholar