Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression

Figure 1

Expressions of PD-1/PD-L1 on CD4⁺ T cells and monocytes in early-stage septic shock patients. Percentages of PD-1 and PD-L1 expressions on CD4⁺ T cells and monocytes were compared between septic shock patients () and healthy volunteers (): (a) percentage of PD-1 expression on CD4⁺ T cells; (b) percentage of PD-L1 expression on CD4⁺ T cells; (c) percentage of PD-1 expression on monocytes; (d) percentage of PD-L1 expression on monocytes. The percentages of PD-1 expression on CD4⁺ T cells (e) and monocytes (f) were compared between patients with APACHE II scores > 20 () and < 20 (). These expressions on monocytes were also compared between survivors () and nonsurvivors (): (g) percentages of PD-1 expression; (h) percentages of PD-L1 expression. Each dot represents one individual value. Analyses were conducted using the Mann-Whitney rank sum test. , .

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