Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression
Notch molecules mRNA levels in PBMCs from patients at early stage of septic shock. Total RNA was extracted from PBMCs of patients within 24 hours once septic shock was diagnosed. The mRNA levels of Jagged1 (a) and Hes1 (b) were compared between patients and healthy volunteers. (c) Jagged1 mRNA level was compared between survivors and nonsurvivors with septic shock. Data are normalized to β-actin mRNA and presented as . , .