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Mediators of Inflammation
Volume 2015, Article ID 543541, 11 pages
Research Article

Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma

1Analytical BioSciences, LACDR, Leiden University, P.O. Box 9502, 2300 RA Leiden, Netherlands
2Sino-Dutch Centre for Preventive and Personalized Medicine, Leiden University, P.O. Box 9502, 2300 RA Leiden, Netherlands
3SU Biomedicine, Utrechtseweg 48, 3700 AJ Zeist, Netherlands
4Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium
5TNO Innovation for Life, P.O. Box 360, 3700 AJ Zeist, Netherlands
6Tohoku Institute of Technology, Sendai 982-8577, Japan

Received 28 August 2015; Accepted 8 October 2015

Academic Editor: Nina Ivanovska

Copyright © 2015 Min He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The supplementary material provides the methodology of oxylipin extraction and detection and reports performance characteristics of this method. Detailed results from supervised. PLS-DA analysis and VIP scores are also provided in order to demonstrate the important contributions of significant oxylipins to the group clusters.

  1. Supplementary Material