Pivotal Roles of GM-CSF in Autoimmunity and Inflammation

Table 1

Clinical trials targeting GM-CSF.

Target	Drug	Type	Indication	Phase	Status
GM-CSFR	Mavrilimumab; (CAM-3001)	mAb	RA	II	Completed
GM-CSF	MOR103	mAb	RA; MS	Ib/IIa; Ib	Completed; Completed, not published yet
GM-CSF	Namilumab; (MT203)	mAb	RA; Plaque psoriasis	I; II	Completed, not published yet; On-going
GM-CSF	KB003	Humaneered mAb	RA; Asthma	II; II	Terminated, not published yet; Completed, not published yet
GM-CSF	MORAb-022	mAb	RA	I	On-going

GM-CSFR: GM-CSF receptor; mAb: monoclonal antibody; RA: rheumatoid arthritis; MS: multiple sclerosis.