Bromoenol Lactone, an Inhibitor of Calcium-Independent Phospholipase A₂, Suppresses Carrageenan-Induced Prostaglandin Production and Hyperalgesia in Rat Hind Paw

Figure 1

Contents of PGE₂ (a) and 6-keto-PGF_1α (b) in rat hind paw. Carrageenan (Car) injection (filled bars) significantly elevated both prostaglandin levels compared to saline (Sal) injection (open bars) in vehicle-, BEL-, and AACOCF₃- (AACO-) treated groups (–0.014, t-test, in each group). BEL but not AACOCF₃ significantly suppressed carrageenan-induced increases in PGE₂ (a) and 6-keto-PGF_1α (b) compared to vehicle ( for PGE₂ and for 6-keto-PGF_1α, multiple t-tests with Bonferroni correction, 2 comparisons among 3 groups; vehicle versus BEL and vehicle versus AACOCF₃). Asterisks indicate the statistical significance of the difference between vehicle + carrageenan group and BEL + carrageenan group.

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