Mediators of Inflammation / 2015 / Article / Fig 1

Research Article

Bromoenol Lactone, an Inhibitor of Calcium-Independent Phospholipase A2, Suppresses Carrageenan-Induced Prostaglandin Production and Hyperalgesia in Rat Hind Paw

Figure 1

Contents of PGE2 (a) and 6-keto-PGF1α (b) in rat hind paw. Carrageenan (Car) injection (filled bars) significantly elevated both prostaglandin levels compared to saline (Sal) injection (open bars) in vehicle-, BEL-, and AACOCF3- (AACO-) treated groups (–0.014, t-test, in each group). BEL but not AACOCF3 significantly suppressed carrageenan-induced increases in PGE2 (a) and 6-keto-PGF1α (b) compared to vehicle ( for PGE2 and for 6-keto-PGF1α, multiple t-tests with Bonferroni correction, 2 comparisons among 3 groups; vehicle versus BEL and vehicle versus AACOCF3). Asterisks indicate the statistical significance of the difference between vehicle + carrageenan group and BEL + carrageenan group.
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(b)

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