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Mediators of Inflammation
Volume 2015, Article ID 607363, 11 pages
http://dx.doi.org/10.1155/2015/607363
Review Article

Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis

1Immunology Department, National School of Biological Sciences, National Polytechnic Institute, Plan de Ayala y Prolongación de Carpio S/N, Colonia Santo Tomás, Miguel Hidalgo, 11340 Mexico City, DF, Mexico
2Microbiology Department, National School of Biological Sciences, National Polytechnic Institute, Plan de Ayala y Prolongación de Carpio S/N, Colonia Santo Tomás, Miguel Hidalgo, 11340 Mexico City, DF, Mexico

Received 13 March 2015; Accepted 21 May 2015

Academic Editor: Julio Galvez

Copyright © 2015 Azael Torales-Cardeña et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Psoriasis is a chronic inflammatory skin disease where the altered regulation in angiogenesis, inflammation, and proliferation of keratinocytes are the possible causes of the disease, and the transcription factor “hypoxia-inducible factor 1-alpha” (HIF-1α) is involved in the homeostasis of these three biological phenomena. In this review, the role of HIF-1α in the cross talk between the cytokines and cells of the immunological system involved in the pathogenesis of psoriasis is discussed.