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Mediators of Inflammation
Volume 2015, Article ID 614357, 8 pages
http://dx.doi.org/10.1155/2015/614357
Research Article

Influence of Malondialdehyde and Matrix Metalloproteinase-9 on Progression of Carotid Atherosclerosis in Chronic Renal Disease with Cardiometabolic Syndrome

1Clinic for Nephrology, Clinical Center University Sarajevo, Bosnia and Herzegovina
2Department of Medical Biochemistry, Faculty of Medicine University of Sarajevo, Bosnia and Herzegovina
3Clinic for Abdominal Surgery, Clinical Center University Sarajevo, Bosnia and Herzegovina
4Clinic for Immunology University Clinical Centre Sarajevo, Bosnia and Herzegovina

Received 12 May 2015; Revised 3 September 2015; Accepted 6 September 2015

Academic Editor: Aaron L. Sverdlov

Copyright © 2015 Senija Rašić et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective was to assess whether the concentration of malondialdehyde (MDA) as a marker of lipid peroxidation and serum concentration of matrix metalloproteinase-9 (MMP-9) are involved in the process of atherosclerosis in chronic kidney disease (CKD) patients nondialysis-dependent and those on peritoneal dialysis (PD), both with signs of cardiometabolic syndrome (CMS). Thirty CKD and 22 PD patients were included in a study. All observed patients were divided into three subgroups depending on the degree of atherosclerotic changes in the carotid arteries (CA). Severity of atherosclerotic changes in the CA was evaluated by ultrasonography. We confirmed significantly lower level of serum MDA throughout all the stages of atherosclerosis in PD patients compared with observed CKD patients () and increased serum concentration of MDA and MMP-9 with the progression of severity atherosclerotic changes in both groups of patients. The multiple regression analysis revealed that MDA and MMP-9 are significant predictors of changes in IMT-CA CKD patients () and plaque score on CA in these patients (). The results suggest that MDA and MMP-9 could be mediators of CKD-related vascular remodeling in CMS.