Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents

Figure 1

Body weight and food intake. (a) Body weight of rats fed with high fat (HF) and low fat (LF) diet. (b) Body weight in leptin deficient mice (ob/ob) versus wild type (WT) mice fed ad libitum. (c) Body weight in ob/ob mice fed ad libitum, 36 hours fasted and after leptin treatment in ob/ob mice fed ad libitum. (d) Body weight change in rats fed ad libitum, in 48 h of fasting and in rats submitted to a refeeding for 24 h after 48 h of fasting. (e) Food intake of rats fed with high fat (HF) and low fat (LF) diet. (f) Food intake in leptin deficient mice (ob/ob) versus wild type (WT) mice fed ad libitum. (g) Food intake in ob/ob mice fed ad libitum, 36 hours fasted and after leptin treatment in ob/ob mice fed ad libitum. (h) Food intake in rats fed ad libitum, in 48 h of fasting and in rats submitted to a refeeding for 24 h after 48 h of fasting. Values are mean ± standard error of the mean of 6–12 animals per group. Values are mean ± SEM. ; ; versus controls and ; ; versus FAST 48 h.

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