Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents

Table 1

Body composition and biochemical and hormonal characteristics from the models studied.

Group	Insulin (ng/mL)	Glucose (mg/dL)	Total cholesterol (mg/dL)	Fat mass (g)	Lean mass (g)
Low fat	5.36 ± 1.08	18.51 ± 1.02	6.32 ± 0.40	56.53 ± 5.63	412.3 ± 4.0
High fat	9.07 ± 1.58	25.86 ± 0.96	7.14 ± 0.92	150.02 ± 23.04	435.1 ± 5.5
Wild type mice	2.01 ± 0.42	2.41 ± 0.13	0.78 ± 0.07	—	—
ob/ob mice FED	7.67 ± 1.63	4.40 ± 0.72	1.04 ± 0.03	—	—
ob/ob mice FAST	4.35 ± 0.85	1.94 ± 0.34^##	0.088 ± 0.04	—	—
ob/ob mice FED + OB	1.32 ± 0.97^###	3.24 ± 0.56	0.087 ± 0.02	—	—
Rats FED	1.11 ± 0.22	20.16 ± 2.09	5.09 ± 0.83	26.21 ± 0.88	175.6 ± 3.4
Rats FAST	0.09 ± 0.007	13.23 ± 0.71	8.20 ± 0.32	21.94 ± 0.71	163.5 ± 1.9
Rats REFED	1.13 ± 0.19^##	26.12 ± 0.78	6.14 ± 0.34^#	23.52 ± 1.13	166.6 ± 3.4

Values are mean ± SEM of 7-8 animals per group. ; ; versus controls. ; ^##; ^### versus ob/ob FED and versus FAST 48 h.