Amarogentin Displays Immunomodulatory Effects in Human Mast Cells and Keratinocytes

Figure 2

Impact of amarogentin on IL-6 secretion in stimulated HaCaT keratinocytes. HaCaT cells were costimulated with 100 μM histamine and 25 ng/mL TNF-α and preincubated with amarogentin (100 μM) or the control azelastine (24 μM) for 30 minutes. After 24 h IL-6 expression was assessed in the cell supernatant. The data are shown with standard deviation (SEM) and were analyzed with the unpaired, two-tailed -test (; ns: not statistically significant; ).