Leukocytes: The Double-Edged Sword in Fibrosis

Figure 3

The comprehensive view on complex leukocytes impact on fibrotic tissue formation. The direct impact depends on ECM components production and deposition by leukocytes, such as fibrocytes and wound-healing macrophages. The indirect impact is composed of variety of different chemokines and growth factors interacting with cells, which in turn leads to ECM deposition.