Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest

Table 2

Cytokines with prognostic implications.

	Cytokines involved
	Primary myelofibrosis	Essential thrombocythemia	Polycythemia vera
Low survival; High DIPSS categories	↑ IL8 and/or sIL2Ra [13]; ↑ IL10 [13]; ↑ IL12 [13]; ↑ IL15 [13]	ND	MIP-1β [13]
Progression to myelofibrosis	—	↑ IL2 [16]; ↑ IL2ra [16]	↑ IL2 [16]; ↑ IL2ra [16]
Leukemic transformation	↑ IL8 and/or sIL2Ra [13]; ↑ IL2 and sIL2Ra [6, 8, 16]; ↑ IL6 [6]	ND	ND
Vascular events	ND	ND	↑ IL12 [15]; ↑ GM-CSF [15]

This table represents prognostic values of cytokines described in PV, ET, and PMF. ↑ means increase in cytokine level; ND means not described to our knowledge.