Review Article

Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases

Figure 2

Schematic representation of microglial responses in glaucoma, AMD, and diabetic retinopathy. Reactive microglial cells are found in the retina of patients and animal models of glaucoma (a), AMD (b), and diabetic retinopathy (c). (a) Glaucomatous retinas present abnormally distributed activated microglial cells in the GCL, namely, surrounding the RGC axons and soma. (b) In AMD retinas, microglial cells accumulate in the ONL and subretinal space, surrounding drusen deposits. (c) Increased vascular permeability in diabetic retinopathy is accompanied by perivascular accumulation of activated microglial cells.
(a)
(b)
(c)