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Mediators of Inflammation
Volume 2015, Article ID 680853, 6 pages
http://dx.doi.org/10.1155/2015/680853
Review Article

Increased Risk of Cancer in relation to Gout: A Review of Three Prospective Cohort Studies with 50,358 Subjects

1Department of Neurosurgery, Huai’an First People’s Hospital Affiliated to Nanjing Medical University, 6 Beijing Road West, Huai’an 223300, China
2Department of Rheumatology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
3Liver Transplantation Center of the First Affiliated Hospital and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210002, China
4Department of Endocrinology, The Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China
5Department of Surgical Oncology, The Eighty-First Hospital of People’s Liberation Army, Nanjing 210002, China

Received 15 July 2014; Revised 1 September 2014; Accepted 10 September 2014

Academic Editor: Sydney C. W. Tang

Copyright © 2015 Weijie Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevant studies published to date. A comprehensive literature search in PubMed and Embase databases from their inception up to July 1, 2014, was performed to identify eligible studies. The strength for relationship between gout and the risk of different cancers was evaluated by calculating pooled relative risks (RRs) with 95% confidence intervals (95% CIs). All analyses were carried out by STATA 12.0 software. Gout patients were at an increased risk of cancer, particularly urological cancers, digestive system cancers, and lung cancer. No such significant association between gout and the risk of breast or brain cancers was observed. Sensitivity analysis did not materially alter the pooled results. Gout is a risk factor of cancer, particularly that of urological cancers, digestive system cancers, and lung cancer. The pooled data further support the hypothesis of a link between gout and carcinogenesis.