Mediators of Inflammation / 2015 / Article / Fig 4

Research Article

Genetic Deletion of Soluble Epoxide Hydrolase Attenuates Inflammation and Fibrosis in Experimental Obstructive Nephropathy

Figure 4

Deficiency of sEH reduces the leukocyte infiltration and cytokine production. ((a) and (b)) 14 days after UUO surgery, kidneys were harvested. Kidney lysates from WT and sEH−/− mice were immunoblotted with F4/80, CD3, MPO, inducible nitric oxide synthase (iNOS), and GAPDH. (c) The levels of MCP-1, MIP-2, IL-1β, and IL-6 in kidneys were assessed by ELISA kits. Data are mean ± SEM from 8 mice. versus WT nonobstructed kidney; versus WT UUO kidney.

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