Genetic Deletion of Soluble Epoxide Hydrolase Attenuates Inflammation and Fibrosis in Experimental Obstructive Nephropathy

Figure 6

Deletion of sEH does not affect the glomerulosclerosis induced by UUO surgery. (a) 14 days after UUO surgery, kidney specimens from WT and mice were subjected to periodic acid-Schiff staining. Hematoxylin was used for counterstaining. Scale bar: 50 μm. (b) Quantification of histopathology of glomerulosclerosis of kidney. (c) Kidney lysates were immunoblotted with collagen 4A2 (COL4A2) and GAPDH. Data are mean ± SEM from 8 mice. versus WT nonobstructed kidney.

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