Research Article

HMGB-1 as a Novel Predictor of Disease Severity and Prognosis in Patients with Hemorrhagic Fever with Renal Syndrome

Table 5

Predictive values for prognosis with HMGB-1 and laboratory parameters in patients with HFRS.

VariablesAUCa valuebProbability valuecSensitivitycSpecificityc95% Cl for AUC
LowerUpper

HMGB-10.8000.0010.07276.988.00.6450.955
WBC0.8310.0010.11161.591.80.7240.937
dPLT0.8390.0010.14776.979.70.7530.925
dALB0.8060.0010.08276.979.10.6900.922
BUN0.6190.1540.4840.754
Scr0.5520.5320.4290.675
dUA0.6610.0540.5020.820
eCombination0.8920.0010.10384.683.50.8070.977

AUC: area under the curve; CI: confidence interval; HMGB-1: high mobility group box protein-1; WBC: white blood cells; PLT: platelets; HCT: hematocrit; ALB: albumin; BUN: blood urea nitrogen; Scr: serum creatinine; UA: uric acid.
a value for calculated AUC in predicting death.
bProbability values were calculated by logistic regression.
cSensitivity, specificity, and 95% CI are all presented as percentages.
dTest direction: lower test result indicates a more positive test.
eWBC, AST, PLT, and Fib in combination.