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Mediators of Inflammation
Volume 2015, Article ID 701067, 11 pages
Review Article

Distinct Functions of Neutrophil in Cancer and Its Regulation

1Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel
2Translational Oncology, Internal Medicine II, University Hospital, Tuebingen, Otfried-Mueller-Street 10, 72076 Tuebingen, Germany

Received 24 August 2015; Accepted 27 October 2015

Academic Editor: Ronald Gladue

Copyright © 2015 Zvi Granot and Jadwiga Jablonska. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Neutrophils are the most abundant of all white blood cells in the human circulation and are usually associated with inflammation and with fighting infections. In recent years the role immune cells play in cancer has been a matter of increasing interest. In this context the function of neutrophils is controversial as neutrophils were shown to possess both tumor promoting and tumor limiting properties. Here we provide an up-to-date review of the pro- and antitumor properties neutrophils possess as well as the environmental cues that regulate these distinct functions.