Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2015, Article ID 738563, 11 pages
http://dx.doi.org/10.1155/2015/738563
Research Article

Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy

1Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), CCT CONICET, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 1900 La Plata, Argentina
2Departamento de Ciencias Biológicas, Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP), UNLP-CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata, Argentina
3Laboratorio de Inmunología de Enfermedades Respiratorias, Instituto de Medicina Experimental (IMEX), CONICET, Academia Nacional de Medicina, C1425AUM Buenos Aires, Argentina
4Servicio de Gastroenterología, Hospital de Niños “Sor María Ludovica”, 1900 La Plata, Argentina
5Servicio de Gastroenterología, Hospital “San Martín”, 1900 La Plata, Argentina

Received 16 April 2015; Accepted 5 July 2015

Academic Editor: Dezheng Zhao

Copyright © 2015 Natalia M. Bottasso Arias et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Celiac disease (CD) is an immune-mediated enteropathy that develops in genetically susceptible individuals following exposure to dietary gluten. Severe changes at the intestinal mucosa observed in untreated CD patients are linked to changes in the level and in the pattern of expression of different genes. Fully differentiated epithelial cells express two isoforms of fatty acid binding proteins (FABPs): intestinal and liver, IFABP and LFABP, respectively. These proteins bind and transport long chain fatty acids and also have other important biological roles in signaling pathways, particularly those related to PPAR and inflammatory processes. Herein, we analyze the serum levels of IFABP and characterize the expression of both FABPs at protein and mRNA level in small intestinal mucosa in severe enteropathy and normal tissue. As a result, we observed higher levels of circulating IFABP in untreated CD patients compared with controls and patients on gluten-free diet. In duodenal mucosa a differential FABPs expression pattern was observed with a reduction in mRNA levels compared to controls explained by the epithelium loss in severe enteropathy. In conclusion, we report changes in FABPs’ expression pattern in severe enteropathy. Consequently, there might be alterations in lipid metabolism and the inflammatory process in the small intestinal mucosa.