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Mediators of Inflammation
Volume 2015, Article ID 740357, 6 pages
http://dx.doi.org/10.1155/2015/740357
Research Article

Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis

1Institute of Rheumatology, Na Slupi 4, 12850 Prague 2, Czech Republic
2Department of Pathology, Third Faculty of Medicine, Charles University, Šrobárova 50, 100 34 Prague 10, Czech Republic
3Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Salmovská 1, 120 00 Prague 2, Czech Republic
4First Orthopaedic Clinic, First Faculty of Medicine, Charles University, V Úvalu 84, 150 06 Prague 5, Czech Republic
5Department of Rheumatology, First Faculty of Medicine, Charles University, Na Slupi 4, 128 50 Prague 2, Czech Republic

Received 25 June 2014; Revised 28 August 2014; Accepted 15 September 2014

Academic Editor: Peter Huszthy

Copyright © 2014 Lucie Andrés Cerezo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA. Methods. PGRN levels were evaluated in patients with RA () and OA () and healthy controls (). Immunohistochemical analysis of PGRN in synovial tissues was performed. The association between PGRN and C-reactive protein (CRP), disease activity score (DAS28-CRP), and health assessment questionnaire (HAQ) was studied. Results. Circulating PGRN was elevated in patients with RA and OA compared to healthy controls ( and versus  ng/mL; ). Synovial fluid levels of PGRN were higher in patients with RA compared to OA ( versus  ng/mL; ). PGRN expression was significantly upregulated in the synovial tissue of RA patients particularly in the inflammatory infiltrates. Serum PGRN levels correlated with DAS28 (, ) and HAQ score (, ), while synovial fluid PGRN correlated only with HAQ (, ) in patients with RA. PGRN levels were not associated with CRP or autoantibodies. Conclusions. This study demonstrates increased PGRN expression at local sites of inflammation and association between PGRN levels, disease activity, and functional impairment in patients with RA.