Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis

Table 2

Expression ofprogranulin (PGRN) in different cellular compartments of synovial tissue samples from patients with rheumatoid arthritis (RA) and osteoarthritis (OA).

	RA ( = 6)	OA ( = 7)	Jonckheere-Terpstra test
Lining layer	2.42 ± 0.48	1.82 ± 0.52	= 0.086
Sublining layer	2.52 ± 0.28	1.68 ± 0.42	= 0.033
Vessels and capillaries	0.31 ± 0.13	0.33 ± 0.10	= 0.462

The intensity of PGRN expression was scored using semiquantitative four-point scale. Score 0 represented no staining, 1 weak staining, 2 moderate staining, and 3 strong staining intensity. The numbers represent mean ± SD.
PGRN: progranulin; RA: rheumatoid arthritis; OA: osteoarthritis.