Fibrosis Related Inflammatory Mediators: Role of the IL-10 Cytokine Family

Table 1

Inflammatory mediators with pro- and/or antifibrotic effects [27, 46].

	Profibrotic	Antifibrotic
Growth factors	TGF-; PDGF; CTGF; IGF; FGF; EGF; VEGF	HGF
Cytokines	IL-1; IL-4; IL-5; IL-6; IL-13; IL-17; IL-19; IL-20; IL-21; IL-24; IL-33; TNF-; CCL2; CCL3; CCL4; CCL20	IL-7; IL-10; IL-12; IL-22; IFN-γ

TGF: tumor growth factor; PDGF: platelet-derived growth factor; CTGF: connective tissue growth factor; IGF: insulin-like growth factor; FGF: fibroblast growth factor; EGF: epidermal growth factor; VEGF: vascular endothelial growth factor; HGF: hepatocyte growth factor; IL: interleukin; TNF: tumor necrosis factor; CCL: chemokine (C-C motif) ligand; IFN: interferon.