Acute Necrotizing Encephalopathy: An Underrecognized Clinicoradiologic Disorder

Figure 1

Clinical course of acute necrotizing encephalopathy (ANE). Survivors of ANE go through three phases during the clinical course including prodromal stage, period of acute encephalopathy, and recovery stage. In the prodromal stage, the common symptoms include cough, vomiting, diarrhea, skin erythra mainly due to various viral infections. Soon after, the dysfunction of the brain gradually appeared during the acute encephalopathy stage, for example, disturbance of consciousness, seizures, focal deficits. If survived, patients of ANE would go through the third phase, so-called recovery stage, and most patients left with different neurological sequelae while a few could recover completely.