Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2015, Article ID 810948, 6 pages
http://dx.doi.org/10.1155/2015/810948
Research Article

Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats

1Department of Infectious Diseases and Clinical Bacteriology and Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, Turkey
2Department of Infectious Diseases and Clinical Bacteriology, Fatih Sultan Mehmet Training and Research Hospital, 34746 Istanbul, Turkey
3Department of Emergency Medicine, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey
4Department of Biochemistry, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey
5Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey
6Department of Biochemistry, Faculty of Medicine, Namik Kemal University, Tekirdağ, Turkey
7Department of Oncology, Faculty of Medicine, Bahcesehir University, Istanbul, Turkey

Received 23 December 2014; Revised 19 March 2015; Accepted 21 March 2015

Academic Editor: Nina Ivanovska

Copyright © 2015 Ozlem Alici et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. J. Dare, A. R. J. Phillips, A. J. R. Hickey et al., “A systematic review of experimental treatments for mitochondrial dysfunction in sepsis and multiple organ dysfunction syndrome,” Free Radical Biology and Medicine, vol. 47, no. 11, pp. 1517–1525, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Piechota, M. Banach, R. Irzmanski et al., “Plasma endothelin-1 levels in septic patients,” Journal of Intensive Care Medicine, vol. 22, no. 4, pp. 232–239, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Shah, “Endothelins in health and disease,” European Journal of Internal Medicine, vol. 18, no. 4, pp. 272–282, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. V. M. Victor, M. Rocha, J. V. Esplugues, and M. de la Fuente, “Role of free radicals in sepsis: antioxidant therapy,” Current Pharmaceutical Design, vol. 11, no. 24, pp. 3141–3158, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Iba and T. Miyasho, “Danaparoid sodium attenuates the increase in inflammatory cytokines and preserves organ function in endotoxemic rats,” Critical Care, vol. 12, no. 4, article R86, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Ren, Y. Xie, G. Jiang et al., “Apoptotic cells protect mice against lipopolysaccharide-induced shock,” The Journal of Immunology, vol. 180, no. 7, pp. 4978–4985, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. R. F. Guo and P. A. Ward, “Role of oxidants in lung injury during sepsis,” Antioxidants and Redox Signaling, vol. 9, no. 11, pp. 1991–2002, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. P. H. Zapelini, G. T. Rezin, M. R. Cardoso et al., “Antioxidant treatment reverses mitochondrial dysfunction in a sepsis animal model,” Mitochondrion, vol. 8, no. 3, pp. 211–218, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. M. E. Andrades, C. Ritter, and F. Dal-Pizzol, “The role of free radicals in sepsis development,” Frontiers in Bioscience, vol. 1, pp. 277–287, 2009. View at Google Scholar · View at Scopus
  10. A. Ilhan, U. Koltuksuz, S. Ozen, E. Uz, H. Ciralik, and O. Akyol, “The effects of caffeic acid phenethyl ester (CAPE) on spinal cord ischemia/reperfusion injury in rabbits,” European Journal of Cardio-Thoracic Surgery, vol. 16, no. 4, pp. 458–463, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. M. F. Tolba, S. S. Azab, A. E. Khalifa, S. Z. Abdel-Rahman, and A. B. Abdel-Naim, “Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities: a review on its anti-inflammatory, neuroprotective, hepatoprotective, and cardioprotective effects,” IUBMB Life, vol. 65, no. 8, pp. 699–709, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Ghiselli, A. Giacometti, O. Cirioni et al., “Cecropin B enhances betalactams activities in experimental rat models of gram-negative septic shock,” Annals of Surgery, vol. 239, no. 2, pp. 251–256, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Grunberger, R. Banerjee, K. Eisinger et al., “Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis,” Experientia, vol. 44, no. 3, pp. 230–232, 1988. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Ohkawa, N. Ohishi, and K. Yagi, “Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction,” Analytical Biochemistry, vol. 95, no. 2, pp. 351–358, 1979. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Sun, L. W. Oberley, and Y. Li, “A simple method for clinical assay of superoxide dismutase,” Clinical Chemistry, vol. 34, no. 3, pp. 497–500, 1988. View at Google Scholar · View at Scopus
  16. J. X. Wilson, “Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium,” BioFactors, vol. 35, no. 1, pp. 5–13, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Andrades, C. Ritter, M. R. de Oliveira, E. L. Streck, J. C. Fonseca Moreira, and F. Dal-Pizzol, “Antioxidant treatment reverses organ failure in rat model of sepsis: role of antioxidant enzymes imbalance, neutrophil infiltration, and oxidative stress,” Journal of Surgical Research, vol. 167, no. 2, pp. e307–e313, 2011. View at Publisher · View at Google Scholar
  18. J. Figueras-Aloy, L. Gómez-Lopez, M. J. Rodríguez-Miguélez et al., “Plasma endothelin-1 and clinical manifestations of neonatal sepsis,” Journal of Perinatal Medicine, vol. 32, no. 6, pp. 522–526, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Forni, S. Mazzola, L. A. Ribeiro et al., “Expression of endothelin-1 system in a pig model of endotoxic shock,” Regulatory Peptides, vol. 131, no. 1–3, pp. 89–96, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. A. B. Iskit and M. O. Guc, “A new therapeutic approach for the treatment of sepsis,” Medical Hypotheses, vol. 62, no. 3, pp. 342–345, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. D. Konrad, M. Haney, G. Johansson, M. Wanecek, E. Weitzberg, and A. Oldner, “Cardiac effects of endothelin receptor antagonism in endotoxemic pigs,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 293, no. 2, pp. H988–H996, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Ribeiro Nogueira, A. Ramalho, E. Lameu, C. A. da Silva Franca, C. David, and E. Accioly, “Serum concentrations of vitamin A and oxidative stress in critically ill patients with sepsis,” Nutricion Hospitalaria, vol. 24, no. 3, pp. 312–317, 2009. View at Google Scholar · View at Scopus
  23. S. Rinaldi, F. Landucci, and A. R. de Gaudio, “Antioxidant therapy in critically septic patients,” Current Drug Targets, vol. 10, no. 9, pp. 872–880, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Lu, J. Zhen, T. Wu et al., “Superoxide dismutase mimetic drug tempol aggravates anti-GBM antibody-induced glomerulonephritis in mice,” The American Journal of Physiology—Renal Physiology, vol. 299, no. 2, pp. F445–F452, 2010. View at Publisher · View at Google Scholar
  25. I. Hůnová, R. Novotný, H. Uhlířová et al., “The impact of ambient ozone on mountain spruce forests in the Czech Republic as indicated by malondialdehyde,” Environmental Pollution, vol. 158, no. 7, pp. 2393–2401, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. W. Li, M. Ashok, J. Li, H. Yang, A. E. Sama, and H. Wang, “A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1,” PLoS ONE, vol. 2, no. 11, Article ID e1153, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Sauermann, C. Marsik, I. Steiner et al., “Immunomodulatory effects of fosfomycin in experimental human endotoxemia,” Antimicrobial Agents and Chemotherapy, vol. 51, no. 5, pp. 1879–1881, 2007. View at Publisher · View at Google Scholar
  28. H. Zhou, G. Ding, W. Liu et al., “Lipopolysaccharide could be internalized into human peripheral blood mononuclear cells and elicit TNF-alpha release, but not via the pathway of toll-like receptor 4 on the cell surface,” Cellular & Molecular Immunology, vol. 1, no. 5, pp. 373–377, 2004. View at Google Scholar · View at Scopus
  29. C. Pascual, R. Gonzalez, and R. G. Torricella, “Scavenging action of propolis extract against oxygen radicals,” Journal of Ethnopharmacology, vol. 41, no. 1-2, pp. 9–13, 1994. View at Publisher · View at Google Scholar · View at Scopus
  30. W.-K. Jung, I. Choi, D.-Y. Lee et al., “Caffeic acid phenethyl ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 macrophages via the p38/ERK and NF-κB pathways,” International Journal of Biochemistry and Cell Biology, vol. 40, no. 11, pp. 2572–2582, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. C. E. Sandrock and T. E. Albertson, “Controversies in the treatment of sepsis,” Seminars in Respiratory and Critical Care Medicine, vol. 31, no. 1, pp. 66–78, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. D. de Filippis, T. Iuvone, G. Esposito et al., “Melatonin reverses lipopolysaccharide-induced gastro-intestinal motility disturbances through the inhibition of oxidative stress,” Journal of Pineal Research, vol. 44, no. 1, pp. 45–51, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. B. T. Bilen, H. Kilinç, N. Alaybeyoglu et al., “Effect of caffeic acid phenethyl ester on survival of axial pattern flaps in rats with ischaemia-reperfusion injuries,” Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, vol. 40, no. 2, pp. 73–78, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. H. Fidan, O. Sahin, Y. Yavuz et al., “Caffeic acid phenethyl ester reduces mortality and sepsis-induced lung injury in rats,” Critical Care Medicine, vol. 35, no. 12, pp. 2822–2829, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. C. Ara, A. Dirican, S. Erdoğan et al., “The effect of caffeic acid phenethyl ester on bacterial translocation and intestinal damage after intestinal obstruction,” Turkish Journal of Medical Sciences, vol. 40, no. 6, pp. 897–903, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. O. G. Yildiz, S. Soyuer, R. Saraymen, and C. Eroglu, “Protective effects of caffeic acid phenethyl ester on radiation induced lung injury in rats,” Clinical and Investigative Medicine, vol. 31, no. 5, pp. E242–E247, 2008. View at Google Scholar · View at Scopus
  37. J. J. Haddad and C. S. Fahlman, “Nuclear factor-κB-independent regulation of lipopolysaccharide-mediated interleukin-6 biosynthesis,” Biochemical and Biophysical Research Communications, vol. 291, no. 4, pp. 1045–1051, 2002. View at Publisher · View at Google Scholar · View at Scopus
  38. F. Armutcu, A. Gürel, M. Hoşnuter, O. Pabuçcu, and C. Altinyazar, “Caffeic acid phenethyl ester improves oxidative erythrocyte damage in a rat model of thermal injury,” Journal of Burn Care & Rehabilitation, vol. 25, no. 2, pp. 171–178, 2004. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Gurel, F. Armutcu, M. Hosnuter, M. Unalacak, E. Kargi, and C. Altinyazar, “Caffeic acid phenethyl ester improves oxidative organ damage in rat model of thermal trauma,” Physiological Research, vol. 53, no. 6, pp. 675–682, 2004. View at Google Scholar · View at Scopus
  40. O. Koksel, M. B. Kaplan, A. Ozdulger et al., “Oleic acid-induced lung injury in rats and effects of caffeic acid phenethyl ester,” Experimental Lung Research, vol. 31, no. 5, pp. 483–496, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. M. K. Ozer, H. Parlakpinar, N. Vardi, Y. Cigremis, M. Ucar, and A. Acet, “Myocardial ischemia/reperfusion-induced oxidative renal damage in rats: protection by caffeic acid phenethyl ester (cape),” Shock, vol. 24, no. 1, pp. 97–100, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. A. M. Mohamadin, L. N. A. Hammad, M. F. El-Bab, and H. S. Abdel Gawad, “Attenuation of oxidative stress in plasma and tissues of rats with experimentally induced hyperthyroidism by caffeic acid phenylethyl ester,” Basic and Clinical Pharmacology and Toxicology, vol. 100, no. 2, pp. 84–90, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. H. Ozyurt, B. Ozyurt, K. Koca, and S. Ozgocmen, “Caffeic acid phenethyl ester (CAPE) protects rat skeletal muscle against ischemia-reperfusion-induced oxidative stress,” Vascular Pharmacology, vol. 47, no. 2-3, pp. 108–112, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. S. C. Barber, A. Higginbottom, R. J. Mead, S. Barber, and P. J. Shaw, “An in vitro screening cascade to identify neuroprotective antioxidants in ALS,” Free Radical Biology and Medicine, vol. 46, no. 8, pp. 1127–1138, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. B. Ozyurt, H. Ozyurt, N. Akpolat, H. Erdogan, and M. Sarsilmaz, “Oxidative stress in prefrontal cortex of rat exposed to MK-801 and protective effects of CAPE,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 31, no. 4, pp. 832–838, 2007. View at Publisher · View at Google Scholar · View at Scopus
  46. A. A. Korish and M. M. Arafa, “Propolis derivatives inhibit the systemic inflammatory response and protect hepatic and neuronal cells in acute septic shock,” Brazilian Journal of Infectious Diseases, vol. 15, no. 4, pp. 332–338, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. Z. Teke, E. B. Bostanci, C. Yenisey et al., “Effects of caffeic acid phenethyl ester on anastomotic healing in secondary peritonitis,” Journal of Investigative Surgery, vol. 25, no. 5, pp. 301–310, 2012. View at Publisher · View at Google Scholar · View at Scopus