Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans

Figure 3

Isoflurane (Iso) and captopril (Cap) reduced postischemic myocardial injury, ameliorated myocardial inflammation, and attenuated cardiac ultrastructural alterations in rabbits. (a) Ratio of area at risk (AAR) to left ventricular (LV), (b) percentage of infarct size (IS) expressed as a percentage of AAR, (c) representative images of electron micrograph of rabbit hearts, (d) plasma cTnI, (e) plasma CK-MB, and (f) lactate dehydrogenase (LDH). Sham: sham operated control; I/R: rabbits subjected to myocardial ischemia reperfusion (MI/R); Cap: rabbits treated with captopril (25 mg/kg given intravenously 24 h) prior to inducing MI/R; Iso: rabbits received isoflurane preconditioning (15 min 1.1% end tidal isoflurane followed by a 15 min washout period before inducing MI/R); Iso+Cap: rabbits received captopril in combination with Iso. Data are shown as means ± SD, with animals per group. or versus I/R, versus IPC, and versus Baseline.

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