Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans

Table 1

Baseline characteristics of the study population.

Item	Control	Cap1hr	Cap3d	Cap1hr+Iso	Cap3d+Iso
Gender (male/female)	14/6	14/6	15/5	13/7	14/6
Age (years)	46.2 ± 5.9	46.8 ± 7.5	44.5 ± 6.9	43.2 ± 7.2	45.3 ± 6.1
Body weight (Kg)	58.2 ± 7.2	61.7 ± 8.1	62.1 ± 9.0	61.2 ± 7.9	59.7 ± 8.3
LVEF (%)	55.2 ± 6.9	55.3 ± 6.9	53.1 ± 7.8	54.2 ± 7.4	56.6 ± 6.3
Premedication
Digoxin ()	6	6	7	5	6
Diuretic ()	8	7	6	7	8

Control: untreated control; Cap1hr: captopril treatment for 1 h before surgery (12.5 mg, p.o., 1 h before surgery); Cap3d: captopril treatment for 3 days (12.5 mg, p.o., 3 times a day) before surgery; Cap1hr+Iso: captopril treatment for 1 h in combination with inhalational isoflurane (Iso) at 1.1% end tidal concentration administrated for 30 min before CPB; Cap3d+Iso: captopril treatment for 3 days in combination with Iso before CPB. Values are means ± S.D. or the number of patients. No significant differences were observed among groups; LVEF: left ventricular ejection fraction.