The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis

Figure 1

Effect of PARP-1 on the TNF-α induced production of inflammatory mediators in RA FLS. TNF-α stimulation induces the activation and the translocation to the nucleus of the transcription factors NF-κB and AP-1. In the nucleus, PARP-1 enzymatic activity and/or direct protein interaction enhances the transcriptional activity of both NF-κB and AP-1, leading to the production of inflammatory mediators.