Mechanisms of Thymoquinone Hepatorenal Protection in Methotrexate-Induced Toxicity in Rats

<div>Effect of thymoquinone (TQ) on inducible nitric oxide synthase (iNOS) immunohistochemical staining of methotrexate- (MTX-) treated rat kidney and liver. Localization of iNOS immunoreactivity (×100) in the kidney (left panel) and liver (right panel) of (a and f) control group, (b and g) TQ-treated group, (c and h) MTX-treated group, and (d and i) concomitant MTX with TQ-treated group, respectively. (e and j) show semiquantitative analysis of iNOS immunohistochemical staining results in kidney and liver, respectively. 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Mediators of Inflammation

fig1

Figure 1

Figure 1: Mechanisms of Thymoquinone Hepatorenal Protection in Methotrexate-Induced Toxicity in Rats 