Cytokine Regulation of Microenvironmental Cells in Myeloproliferative Neoplasms

Figure 2

Targeting of cytokines and microenvironment interaction in myeloproliferative neoplasms. (a) JAK inhibitors reduce the expression of various cytokines in MPN. (b) Antibodies against vascular endothelial growth factor (VEGF) and kinase inhibitors targeting the VEGF receptors (VEGFRs) result in disruption of the VEGF/VEGFR axis. (c) Antibodies and kinase inhibitors targeting the hepatocyte growth factor (HGF) receptor c-MET attenuate the HGF/c-MET axis. (d) Plerixafor inhibits the interaction of stroma derived factor-1 (SDF-1) with its receptor CXCR4 which results in mobilization of leukemic stem cells.

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