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Mediators of Inflammation
Volume 2015, Article ID 870428, 9 pages
Research Article

Tissue Factor in Dermatitis Herpetiformis and Bullous Pemphigoid: Link between Immune and Coagulation System in Subepidermal Autoimmune Bullous Diseases

1Department of Dermatology and Venereology, Medical University of Lodz, Hallera Square 1, 90-497 Lodz, Poland
2Laboratory of Nephropathology, Medical University of Lodz, Pomorska 251 Street, 92-213 Lodz, Poland
3Department of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, Poland
4Department of Social Medicine, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, Poland
5Department of Laboratory Diagnostics, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, Poland

Received 30 August 2015; Revised 27 November 2015; Accepted 10 December 2015

Academic Editor: Sandra Helena Penha Oliveira

Copyright © 2015 Agnieszka Zebrowska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Dermatitis herpetiformis (DH) and bullous pemphigoid (BP) are skin diseases associated with eosinophilic and neutrophilic infiltrations. Although chemokines are critical for the selective accumulation and activation of various leukocyte subsets in the inflammatory process, there are few findings concerning inflammatory cells and production of coagulation factors in blistering diseases. Skin biopsies were taken from 14 patients with DH, 27 with BP, and 20 control subjects. The localization and expression of tissue factor (TF) in skin lesions and perilesional skin were studied by immunohistochemistry and confirmed by Western Blot. Moreover the plasma concentrations of TF were measured by immunoassays. D dimers, fibrinogen, and selected coagulation parameters were measured by routine methods. Expression of TF in the epidermis and in inflammatory influxed cells in dermis was detected in skin biopsies from BP patients. Examined TF expression was detected in perilesional skin of all BP patients too. The expression of TF was not observed in biopsies from healthy people and DH patients. The findings of the study show an increased expression of tissue factor in the lesional and perilesional skin of patients with bullous pemphigoid. The difference in chemokine pattern expression and variations in the cellular infiltration in BP and DH cause variable expression of TF.