IL-4 Inhibits IL-1β-Induced Depressive-Like Behavior and Central Neurotransmitter Alterations

Figure 3

(a) Effect of IL-4 injection 2 hours after injection of i.c.v. IL-1β on 5-HT concentration. Mean (±SEM) concentrations (nanogram per gram) of 5-HT within the mPFC, hippocampus, and hypothalamus among rats. Each value represents the mean ± SEM. , compared to the CSF and , , and compared to the IL-1β treated group. Control, ; IL-1β, ; IL-4 100 ng, ; IL-4 200 ng, . (b) Effect of IL-4 injection 2 hours after injection of i.c.v. IL-1β on SERT and TPH mRNA levels in the brain. Values are means ± SEM. Relative % GAPDH of SERT and TPH mRNA levels within the mPFC and hippocampus among rats. Each value represents the mean ± SEM. compared to the CSF, , , and compared to the IL-1β treated group. Control, ; IL-1β, ; IL-4 100 ng, ; IL-4 200 ng, .

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