Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update

Table 2

Recently reported MMP inhibitors in models of intestinal inflammation. Novel MMP inhibitors, plant extracts tested in IBD models, and existing IBD therapies are included where MMP-9 expression or activity has been measured.

MMP inhibitor	MMPs inhibited	Model	Reference
RO28-2653	MMP-2, -9	DSS (mouse) (acute)	[163]
Ilomastat	MMP-1	TNBS (rat)	[173]
Minocycline	MMP-2, -3, -9, -13	DSS or TNBS (mouse)	[172]
Etiasa (mesalazine)	MMP-2	TNBS (rat)	[30]
Irsogladine maleate	MMP-2	DSS (mouse)	[209]
Infliximab	MMP-1, -2, -3, -9, -13	Human CD (serum and biopsy)	[174, 175]
CC-10004	MMP-3	Mononuclear cells from human CD	[165]
Nitrate-barbiturates	MMP-9	Cytokine stimulated Caco-2 cells	[161]
Auraptene	MMP-7, -2, -9	DSS (mouse)	[180]
coumarin 4-methylesculetin	MMP-9	TNBS (rat)	[181]
Tris(methoxymethoxy)chalcone	MMP-7	TNF-α stimulated HT-29 cells	[182]
Curcumin	MMP-3	Cultured colonic myofibroblasts from IBD patients	[183]
Phenylpropanoid glycosides: teupolioside and verbascoside	MMP-2, -9	DNBS (rat)	[184, 185]
Neovastat	MMP-9	TNBS (rat)	[188]
Αlpha-lipoic	MMP-9	DSS (mouse)	[210]
Cordyceps militaris	MMP-3 and -9	DSS (mouse)	[189]
Calcium (CaHPO4)	MMP-9, -10, -13	HLA-B27 transgenic rat	[190]