Mediators of Inflammation / 2015 / Article / Fig 1

Review Article

HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative Neoplasms

Figure 1

Schematic representation of the potential effects of HSP inhibitors on the main activated pathways in myeloproliferative neoplasms. PI3K (Phosphatidyl-Inositol-3 Kinase), STAT (Signal Transducers and Activators of Transcription), ERK (extracellular signal-regulated kinases), MEK (mitogen-activated protein kinase kinase), HSP (heat shock protein), mTOR (mammalian target of rapamycin), FOXO (Forkhead transcription factors), NF-κB (Nuclear Factor-kappa B), and IKK (Inhibitor of IκB Kinase).

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