HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative Neoplasms

<div>Schematic representation of the potential effects of HSP inhibitors on the main activated pathways in myeloproliferative neoplasms. PI3K (Phosphatidyl-Inositol-3 Kinase), STAT (Signal Transducers and Activators of Transcription), ERK (extracellular signal-regulated kinases), MEK (mitogen-activated protein kinase kinase), HSP (heat shock protein), mTOR (mammalian target of rapamycin), FOXO (Forkhead transcription factors), NF-<i>κ</i>B (Nuclear Factor-kappa B), and IKK (Inhibitor of I<i>κ</i>B Kinase).</div>

Mediators of Inflammation

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Figure 1

Figure 1: HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative Neoplasms 