Lysosome and Cytoskeleton Pathways Are Robustly Enriched in the Blood of Septic Patients: A Meta-Analysis of Transcriptomic Data

Figure 5

Graphical representations of protein interactions enriched for mortality phenotype. We queried the Unified Human Interactome database (UniHI 7) [21] with a list of top 15 transcripts from each of the two pathways. The display was restricted to those interactions (yellow proteins) supported by at least three PubMed references. Molecular network analysis revealed that 22 out of 30 transcripts formed a network with multiple interconnected nodes (hubs) between top genes in both pathways. Importantly, many of the predicted interaction partners (red proteins), including 3 query proteins (MAPK1, CTSA, and NEU1), were associated with the mortality phenotype.