Lysosome and Cytoskeleton Pathways Are Robustly Enriched in the Blood of Septic Patients: A Meta-Analysis of Transcriptomic Data
Table 1
(a) GEO series included in the study for sepsis in human. (b) Patient characteristics, source of infection, and time of data collection.
(a)
GEO accession
Comparison groups
Probe ID
Publication (PMID)
GSE30119
Healthy () versus sepsis ()
48802
22496797
GSE8121
Nonseptic () versus septic shock_day 1 () versus septic shock_day 3 ()
54675
17932561
GSE9692
Normal () versus septic shock ()
54675
18460642
GSE28750
Healthy () versus Sepsis () versus post-surgical ()
54675
21682927
GSE13015
Platform6106: nonsepsis () versus septicemic melioidosis () versus sepsis_other infection ()
48687
19903332
Platform6947: nonsepsis () versus melioidosis () versus sepsis_other infection ()
48803
19903332
GSE21802
Healthy () versus sepsis without MV () versus sepsis with MV ()
48701
20840779
(b)
GEO accession
Patients characteristics
Source of infection
Time of data collection
GSE30119
Age >10 and <18 year-old Septic pediatrics
Blood and marrow or arthritis () Lung () Skin () Only 77 patients had identified positive infecting organism
Different days during hospitalization ≤3 days () 3–7 days () ≥7 days ()
GSE8121
Age <10 year-old Septic shock pediatrics
Blood (15) Lung (3) Urine (1) Retropharyngeal abscess (1) Only 20 patients had identified positive infecting organism
(1) Within 24 h of admission to ICU (day 1) (2) 48 h after day 1 (day 3)
GSE9692
Age <10 year-old Septic shock pediatrics
Blood (10) Lung (1) Cerebral spinal fluid (1) Other (2) Retropharyngeal abscess (1) Only 15 patients had identified positive infecting organism
Within 24 h of admission to ICU
GSE28750
Age >18 year-old BMI < 40 Septic patients
All blood
Septic patients: within 24 h of admission Post-surgical patients: within 24 h following surgery
GSE13015
Age >18 year-old Septic patients
All blood
Within 7 days of diagnose
GSE21802
Age >18 and <65 year-old Septic patients with confirmed H1N1 infection
Lung ()
Early period (before day 9 in the course of the disease) Late period (from day 9 in the course of the disease)
GSE13015 was a published study using 2 different microarray platforms and in different patients, therefore was considered as two separate studies in the statistical analysis.
