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Mediators of Inflammation
Volume 2016, Article ID 1045657, 10 pages
Research Article

Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1β Axis in Microglia

1Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, China
2Department of Anesthesiology, Chengdu Military General Hospital, 270 Tianhui Road, Chengdu 610083, China
3The Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, 209 Victoria Street, Toronto, ON, Canada M5B 1T8
4Department of Surgery, St. Michael’s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, Canada M5B 1W8

Received 17 September 2015; Revised 24 December 2015; Accepted 31 December 2015

Academic Editor: Ana Garcia-Osta

Copyright © 2016 Da-ming Sui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [12 citations]

The following is the list of published articles that have cited the current article.

  • Rong Gao, Mu-huo Ji, Da-peng Gao, Run-hua Yang, Shao-gang Zhang, Jian-jun Yang, and Jin-chun Shen, “Neuroinflammation-Induced Downregulation of Hippocampacal Neuregulin 1-ErbB4 Signaling in the Parvalbumin Interneurons Might Contribute to Cognitive Impairment in a Mouse Model of Sepsis-Associated Encephalopathy,” Inflammation, vol. 40, no. 2, pp. 387–400, 2016. View at Publisher · View at Google Scholar
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  • Mineji Hayakawa, Yuji Morimoto, and Koji Hoshino, “Minocycline Prevents the Impairment of Hippocampal Long-Term Potentiation in the Septic Mouse,” Shock, vol. 48, no. 2, pp. 209–214, 2017. View at Publisher · View at Google Scholar
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  • Xiangsheng Zhang, Qi Wu, Qingrong Zhang, Yue Lu, Jingpeng Liu, Wei Li, Shengyin Lv, Mengliang Zhou, Xin Zhang, and Chunhua Hang, “Resveratrol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage via Inhibition of NLRP3 Inflammasome Activation,” Frontiers in Neuroscience, vol. 11, 2017. View at Publisher · View at Google Scholar
  • Sahil Gupta, Chan-Mi Lee, Jia-Feng Wang, Jean Parodo, Song-Hui Jia, Jim Hu, and John C. Marshall, “Heat-shock protein-90 prolongs septic neutrophil survival by protecting c-Src kinase and caspase-8 from proteasomal degradation,” Journal of Leukocyte Biology, 2018. View at Publisher · View at Google Scholar
  • Shao-Feng Mou, Li-Li Gong, Zhong-Xin Zhou, Xiao-Qin Chen, and Wen-Sheng Ge, “Anti-inflammatory activity of resveratrol prevents inflammation by inhibiting NF-κB in animal models of acute pharyngitis,” Molecular Medicine Reports, vol. 17, no. 1, pp. 1269–1274, 2018. View at Publisher · View at Google Scholar
  • Yan Fu, Jianmei Yang, Xingyu Wang, Pin Yang, Yang Zhao, Kun Li, Yongjun Chen, and Ying Xu, “Herbal Compounds Play a Role in Neuroprotection through the Inhibition of Microglial Activation,” Journal of Immunology Research, vol. 2018, pp. 1–8, 2018. View at Publisher · View at Google Scholar