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Mediators of Inflammation
Volume 2016, Article ID 1062586, 13 pages
http://dx.doi.org/10.1155/2016/1062586
Research Article

Krüppel-Like Factor 4 Is a Regulator of Proinflammatory Signaling in Fibroblast-Like Synoviocytes through Increased IL-6 Expression

1Department of Basic Medical Sciences, School of Medicine, Taizhou University, Taizhou, Zhejiang 318000, China
2Institute of Tumor Research, School of Medicine, Taizhou University, Taizhou 318000, China
3Department of Orthopedics and Sports Medicine, Taizhou Municipal Hospital, Taizhou 318000, China
4Department of Cardiology, Yingzhou District Second People’s Hospital, Ningbo 315000, China

Received 12 February 2016; Revised 9 May 2016; Accepted 23 May 2016

Academic Editor: Nona Janikashvili

Copyright © 2016 Xinjing Luo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Ritchlin, “Fibroblast biology. Effector signals released by the synovial fibroblast in arthritis,” Arthritis Research, vol. 2, no. 5, pp. 356–360, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. J. J. Goronzy and C. M. Weyand, “Developments in the scientific understanding of rheumatoid arthritis,” Arthritis Research and Therapy, vol. 11, article 249, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. G. R. Burmester, B. Stuhlmüller, G. Keyszer, and R. W. Kinne, “Mononuclear phagocytes and rheumatoid synovitis: mastermind or workhorse in arthritis?” Arthritis and Rheumatism, vol. 40, no. 1, pp. 5–18, 1997. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Bartok and G. S. Firestein, “Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis,” Immunological Reviews, vol. 233, no. 1, pp. 233–255, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Nanki, K. Nagasaka, K. Hayashida, Y. Saita, and N. Miyasaka, “Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritis,” The Journal of Immunology, vol. 167, no. 9, pp. 5381–5385, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. X. Luo, X. Zuo, Y. Zhou et al., “Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes,” Arthritis Research and Therapy, vol. 10, article R41, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Loetscher, B. Dewald, M. Baggiolini, and M. Seitz, “Monocyte chemoattractant protein 1 and interleukin 8 production by rheumatoid synoviocytes. Effects of anti-rheumatic drugs,” Cytokine, vol. 6, no. 2, pp. 162–170, 1994. View at Publisher · View at Google Scholar · View at Scopus
  8. P. K. K. Wong, I. K. Campbell, P. J. Egan, M. Ernst, and I. P. Wicks, “The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover,” Arthritis and Rheumatism, vol. 48, no. 5, pp. 1177–1189, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Nakahara and N. Nishimoto, “Anti-interleukin-6 receptor antibody therapy in rheumatic diseases,” Endocrine, Metabolic and Immune Disorders—Drug Targets, vol. 6, no. 4, pp. 373–381, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Nishimoto, T. Kishimoto, and K. Yoshizaki, “Anti-interleukin 6 receptor antibody treatment in rheumatic disease,” Annals of the Rheumatic Diseases, vol. 59, no. 1, pp. i21–i27, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Miyazawa, A. Mori, K. Yamamoto, and H. Okudaira, “Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: spontaneous activation of NF-κB and CBF1,” The American Journal of Pathology, vol. 152, no. 3, pp. 793–803, 1998. View at Google Scholar · View at Scopus
  12. C. Georganas, H. Liu, H. Perlman, A. Hoffmann, B. Thimmapaya, and R. M. Pope, “Regulation of IL-6 and IL-8 expression in rheumatoid arthritis synovial fibroblasts: the dominant role for NF-κB but not C/EBPβ or c-Jun,” Journal of Immunology, vol. 165, no. 12, pp. 7199–7206, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. J. M. Shields, R. J. Christy, and V. W. Yang, “Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest,” The Journal of Biological Chemistry, vol. 271, no. 33, pp. 20009–20017, 1996. View at Publisher · View at Google Scholar · View at Scopus
  14. M. W. Feinberg, Z. Cao, A. K. Wara, M. A. Lebedeva, S. SenBanerjee, and M. K. Jain, “Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages,” The Journal of Biological Chemistry, vol. 280, no. 46, pp. 38247–38258, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. J. P. Katz, N. Perreault, B. G. Goldstein et al., “The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon,” Development, vol. 129, no. 11, pp. 2619–2628, 2002. View at Google Scholar · View at Scopus
  16. J. A. Segre, C. Bauer, and E. Fuchs, “Klf4 is a transcription factor required for establishing the barrier function of the skin,” Nature Genetics, vol. 22, no. 4, pp. 356–360, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Takahashi and S. Yamanaka, “Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors,” Cell, vol. 126, no. 4, pp. 663–676, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. Z. Cao, X. Sun, B. Icli, A. K. Wara, and M. W. Feinberg, “Role of Krüppel-like factors in leukocyte development, function, and disease,” Blood, vol. 116, no. 22, pp. 4404–4414, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Hamik, Z. Lin, A. Kumar et al., “Kruppel-like factor 4 regulates endothelial inflammation,” The Journal of Biological Chemistry, vol. 282, no. 18, pp. 13769–13779, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. B. Shen, R. S. Smith Jr., Y.-T. Hsu, L. Chao, and J. Chao, “Kruppel-like factor 4 is a novel mediator of kallistatin in inhibiting endothelial inflammation via increased endothelial nitric-oxide synthase expression,” The Journal of Biological Chemistry, vol. 284, no. 51, pp. 35471–35478, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Tsung, S. Tohme, and T. R. Billiar, “High-mobility group box-1 in sterile inflammation,” Journal of Internal Medicine, vol. 276, no. 5, pp. 425–443, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. Z.-W. He, Y.-H. Qin, Z.-W. Wang, Y. Chen, Q. Shen, and S.-M. Dai, “HMGB1 acts in synergy with lipopolysaccharide in activating rheumatoid synovial fibroblasts via p38 MAPK and NF- B signaling pathways,” Mediators of Inflammation, vol. 2013, Article ID 596716, 10 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. J. A. Nogueira-Machadoa and C. M. de Oliveira Volpea, “HMGB-1 as a target for inflammation controlling,” Recent Patents on Endocrine, Metabolic and Immune Drug Discovery, vol. 6, no. 3, pp. 201–209, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Yu, H. Wang, A. Ding et al., “HMGB1 signals through toll-like receptor (TLR) 4 and TLR2,” Shock, vol. 26, no. 2, pp. 174–179, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. J. S. Park, D. Svetkauskaite, Q. He et al., “Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein,” The Journal of Biological Chemistry, vol. 279, no. 9, pp. 7370–7377, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Liu, Y. Liu, H. Zhang, G. Chen, K. Wang, and X. Xiao, “KLF4 promotes the expression, translocation, and release of HMGB1 in RAW264.7 macrophages in response to LPS,” Shock, vol. 30, no. 3, pp. 260–266, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. F. C. Arnett, S. M. Edworthy, D. A. Bloch et al., “The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis,” Arthritis & Rheumatism, vol. 31, no. 3, pp. 315–324, 1988. View at Publisher · View at Google Scholar · View at Scopus
  28. X. Luo, X. Zuo, B. Zhang et al., “Release of heat shock protein 70 and the effects of extracellular heat shock protein 70 on the production of IL-10 in fibroblast-like synoviocytes,” Cell Stress and Chaperones, vol. 13, no. 3, pp. 365–373, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. X. Luo, X. Zuo, X. Mo, Y. Zhou, and X. Xiao, “Treatment with recombinant Hsp72 suppresses collagen-induced arthritis in mice,” Inflammation, vol. 34, no. 5, pp. 432–439, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. D. K. Kaushik, M. Gupta, S. Das, and A. Basu, “Krüppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation,” Journal of Neuroinflammation, vol. 7, article 68, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method,” Methods, vol. 25, no. 4, pp. 402–408, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. J. M. Rosenzweig, J. D. Glenn, P. A. Calabresi, and K. A. Whartenby, “KLF4 modulates expression of IL-6 in dendritic cells via both promoter activation and epigenetic modification,” The Journal of Biological Chemistry, vol. 288, no. 33, pp. 23868–23874, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Miyazawa, A. Mori, H. Miyata, M. Akahane, Y. Ajisawa, and H. Okudaira, “Regulation of interleukin-1β-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase,” The Journal of Biological Chemistry, vol. 273, no. 38, pp. 24832–24838, 1998. View at Publisher · View at Google Scholar · View at Scopus
  34. L. Neff, M. Zeisel, J. Sibilia, M. Schöller-Guinard, J.-P. Klein, and D. Wachsmann, “NF-κB and the MAP kinases/AP-1 pathways are both involved in interleukin-6 and interleukin-8 expression in fibroblast-like synoviocytes stimulated by protein I/II, a modulin from oral streptococci,” Cellular Microbiology, vol. 3, no. 10, pp. 703–712, 2001. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Liu, H. Zhang, Y. Liu et al., “KLF4 regulates the expression of interleukin-10 in RAW264.7 macrophages,” Biochemical and Biophysical Research Communications, vol. 362, no. 3, pp. 575–581, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. M. W. Feinberg, A. K. Wara, Z. Cao et al., “The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation,” EMBO Journal, vol. 26, no. 18, pp. 4138–4148, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. J. K. Alder, R. W. Georgantas III, R. L. Hildreth et al., “Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo,” Journal of Immunology, vol. 180, no. 8, pp. 5645–5652, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. J. An, S. Golech, J. Klaewsongkram et al., “Krüppel-like factor 4 (KLF4) directly regulates proliferation in thymocyte development and IL-17 expression during Th17 differentiation,” The FASEB Journal, vol. 25, no. 10, pp. 3634–3645, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. L. Medugno, F. Florio, E. Cesaro et al., “Differential expression and cellular localization of ZNF224 and ZNF255, two isoforms of the Krüppel-like zinc-finger protein family,” Gene, vol. 403, no. 1-2, pp. 125–131, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. N. Nishimoto, “Interleukin-6 in rheumatoid arthritis,” Current Opinion in Rheumatology, vol. 18, no. 3, pp. 277–281, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. T. Matsumoto, T. Tsurumoto, and H. Shindo, “Interleukin-6 levels in synovial fluids of patients with rheumatoid arthritis correlated with the infiltration of inflammatory cells in synovial membrane,” Rheumatology International, vol. 26, no. 12, pp. 1096–1100, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Al-Awadhi, S. Olusi, N. Al-Zaid, and K. Prabha, “Serum concentrations of interleukin 6, osteocalcin, intact parathyroid hormone, and markers of bone resorption in patients with rheumatoid arthritis,” Journal of Rheumatology, vol. 26, no. 6, pp. 1250–1256, 1999. View at Google Scholar · View at Scopus
  43. S. Kotake, K. Sato, K. J. Kim et al., “Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation,” Journal of Bone and Mineral Research, vol. 11, no. 1, pp. 88–95, 1996. View at Google Scholar · View at Scopus
  44. R. Madhok, A. Crilly, J. Watson, and H. A. Capell, “Serum interleukin 6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity,” Annals of the Rheumatic Diseases, vol. 52, no. 3, pp. 232–234, 1993. View at Publisher · View at Google Scholar · View at Scopus
  45. W. P. Arend and J.-M. Dayer, “Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis,” Arthritis and Rheumatism, vol. 33, no. 3, pp. 305–315, 1990. View at Publisher · View at Google Scholar · View at Scopus
  46. M. Odeh, “New insights into the pathogenesis and treatment of rheumatoid arthritis,” Clinical Immunology and Immunopathology, vol. 83, no. 2, pp. 103–116, 1997. View at Publisher · View at Google Scholar · View at Scopus
  47. E. Choy, “Interleukin 6 receptor as a target for the treatment of rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 62, supplement 2, pp. ii68–ii69, 2003. View at Google Scholar
  48. T. Yoshida, M. Yamashita, C. Horimai, and M. Hayashi, “Deletion of Krüppel-like factor 4 in endothelial and hematopoietic cells enhances neointimal formation following vascular injury,” Journal of the American Heart Association, vol. 3, no. 1, Article ID e000622, 2014. View at Publisher · View at Google Scholar · View at Scopus