Genetic Investigation of Complement Pathway Genes in Type 2 Diabetic Retinopathy: An Inflammatory Perspective
Table 2
Comparison of genotype and allele frequencies of SERPING1 and C5 polymorphisms in DR patients and DM controls.
SNP ID
Minor allele
Allele distribution (%)
P value
Odds ratio (95% CI)
Genotype distribution (%)
P value
Odds ratio (95% CI)
DR ()
DM ()
DR ()
DM ()
C1INH (SERPING1)
rs1005511
G
G
137 (23.2)
125 (22.7)
0.84
173/107/15
165/95/15
0.74
A
453 (76.8)
425 (77.3)
0.84
rs3824988
C
C
71 (12.0)
57 (10.4)
0.37
228/63/4
220/53/2
0.43
T
519 (88.0)
493 (89.6)
0.68
C5
rs12237774
T
T
107 (18.1)
109 (19.8)
0.47
199/85/11
175/91/9
0.34
C
483 (81.9)
441 (80.2)
0.82
rs2269066
T
T
121 (20.5)
120 (21.8)
0.59
187/95/13
165/100/10
0.41
C
469 (79.5)
430 (78.2)
0.64
rs17611
G
G
210 (35.6)
226 (41.1)
0.056
0.79 (0.62–1.0)
117/146/32
100/124/51
0.42
0.53 (0.33–0.86)
A
380 (64.4)
324 (58.9)
0.009 (0.072)
rs1548782
T
T
119 (20.2)
112 (20.4)
0.94
191/89/15
172/94/9
0.59
A
471 (79.8)
438 (79.6)
0.28
rs10985126
C
C
136 (23.1)
134 (24.4)
0.60
170/114/11
160/96/19
0.89
T
454 (76.9)
416 (75.6)
0.089
rs1017119
C
C
73 (12.4)
78 (14.2)
0.37
225/67/3
202/68/5
0.44
T
517 (87.6)
472 (85.8)
0.49
Data are the number of subjects (% of the total group). DR: diabetic retinopathy; DM: diabetes mellitus; Fisher exact test; value for dominant model; value for recessive model. The genotype distribution was showed as major allele homozygous/heterozygous/minor allele homozygous.
