Irbesartan Ameliorates Diabetic Nephropathy by Suppressing the RANKL-RANK-NF-κB Pathway in Type 2 Diabetic db/db Mice

Figure 1

Irb alleviated diabetes-induced renal dysfunction. (a) BUN was increased in db/db mice and reversed significantly by Irb. (b) Scr was increased in db/db mice and reversed significantly by Irb. (c) ACR increased dramatically in db/db mice in an age-dependent method, but this increase was reversed significantly by Irb. The bars in panel (a–c) show the mean expression level in arbitrary units (error bars, S.D.). compared with db/m; compared with db/db, -test.

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