P-Selectin Targeted Dexamethasone-Loaded Lipid Nanoemulsions: A Novel Therapy to Reduce Vascular Inflammation

Figure 3

Adhesion (a) and transmigration (b) of monocytes (THP-1 line) to/through TNF-α activated EC in the presence of dexamethasone either free (Dex) or encapsulated in nontargeted (LN-Dex) or P-selectin targeted (PLN-Dex) lipid nanoemulsions. Empty nontargeted (LN) or P-selectin targeted lipid nanoemulsions (PLN) were used as controls. The data are expressed as mean ± SD of three independent experiments. significantly different from TNF-α-activated EC.

(a)

(b)