P-Selectin Targeted Dexamethasone-Loaded Lipid Nanoemulsions: A Novel Therapy to Reduce Vascular Inflammation

Figure 5

(a) Systemic increase of IL-1β mRNA levels in homogenates of lungs, liver, kidneys, and brain of LPS-treated mice, as determined by RT-PCR and normalized to beta-actin mRNA level. (b) The effect of administration of free dexamethasone (Dex) or encapsulated in nontargeted (LN-Dex) or P-selectin targeted (PLN-Dex) lipid nanoemulsions in LPS-injected mice on mRNA levels of IL-1β, TNF-α, IL-6, and MCP-1 in lungs homogenates as determined by quantitative RT-PCR and normalized to beta-actin mRNA level. Empty PLN were used as control nanoemulsions. Results are expressed as fold induction over the PBS-treated mice, considered as 1. The data are expressed as mean ± SD; = 3–6 mice per group; statistically significant versus LPS (+).

(a)

(b)