Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT

Table 2

median values from all outcome parameters and the value of median test.

	⁢ median values		value
	Placebo	Tr14
Muscle damage and recovery
CK	1.7 × 10^6	1.1 × 10^6	0.05
LDH	1.0 × 10^5	6.1 × 10^4	0.06
Strength (extension)	−2.7 × 10^5	−2.2 × 10^5	0.87
Strength (flexion)	−1.2 × 10^5	−8.7 × 10^4	0.30
Pain score, total	1.2 × 10^5	1.4 × 10^5	0.36
Pain score, VAS	9.3 × 10^4	1.1 × 10^5	0.36
White blood cell count
Basophils	0	0	0.85
Basophils absolute	−5.4	−6.9	0.41
Eosinophils	−1.2 × 10^3	−2.2 × 10^3	0.41
Eosinophils absolute	−58.3	−66.0	0.41
Leukocytes	2.2 × 10^3	3.4 × 10^3	0.92
Lymphocytes	−1.7 × 10^4	−7.9 × 10^3	0.02
Lymphocytes absolute	−3.9 × 10^2	−1.2 × 10^2	0.21
Monocytes	−4.1 × 10^2	−4.0 × 10^3	0.21
Monocytes absolute	1.4 × 10^2	63.2	0.41
Neutrophils	2.0 × 10^4	1.4 × 10^4	0.21
Neutrophils absolute	3.4 × 10^3	2.3 × 10^3	0.10
Lymphocyte activation and apoptosis
Annexin V	−1.9 × 10^3	−3.7 × 10^3	0.67
Annexin V absolute	−44.5	−66.2	0.92
CD62	4.1 × 10^3	−4.7 × 10^3	0.21
CD62L absolute	−2.9 × 10^2	−1.6 × 10^2	0.60
CD69	1.1 × 10^2	2.8 × 10^2	0.41
CD69 absolute	−0.4	5.4	0.07
CD95R	3.1 × 10^3	5.9 × 10^3	0.18
CD95R absolute	−0.8	36.2	0.20
CD95L	−5.5 × 10^2	5.1 × 10^3	0.47
CD95L absolute	−7.0	40.5	0.34
Soluble inflammatory mediators
CXCL8	4.9 × 10^7	3.0 × 10^7	0.40
CXCL8 serum	1.2 × 10^3	1.9 × 10^3	0.60
CCL2	8.6 × 10^6	4.0 × 10^7	0.40
CCL2 serum	1.4 × 10^5	1.3 × 10^5	0.61
CCL3	5.0 × 10^7	3.8 × 10^7	0.40
CCL4	2.7 × 10^8	3.4 × 10^8	0.67
CCL11	−1.3 × 10^4	−6.3 × 10^4	0.20
Factor VII	2.5 × 10^4	−3.8 × 10^4	0.40
ICAM-1	1.3 × 10^4	−2.9 × 10^3	0.01
IFN-γ	2.6 × 10^6	2.3 × 10^6	0.67
IL-1α	2.3 × 10^2	2.6 × 10^2	0.67
IL-1β	1.4 × 10^7	9.0 × 10^6	0.40
IL-1β serum	3.8 × 10^2	3.2 × 10^−7	0.46
IL-1ra	4.5 × 10^6	4.5 × 10^6	1.00
IL-1ra serum	−4.8 × 10^4	1.8 × 10^4	0.34
IL-2	−2.4 × 10^5	−4.0 × 10^4	0.40
IL-4	−3.0 × 10^4	3.8 × 10^4	0.67
IL-5	1.0 × 10^3	4.6 × 10^3	0.20
IL-6	3.8 × 10^7	2.9 × 10^7	0.67
IL-6 serum	0	0	0.50
IL-7	4.0 × 10^4	3.5 × 10^3	0.67
IL-10	1.9 × 10^5	2.1 × 10^4	0.40
IL-12p40	2.3 × 10^3	5.0 × 10^3	0.67
IL-12p70	−8.6 × 10^4	1.7 × 10^4	0.03
IL-15	6.1 × 10^2	5.0 × 10^2	0.40
IL-17	−5.4 × 10^3	−3.9 × 10^3	1.00
IL-18	2.0 × 10^5	1.0 × 10^5	0.09
IL-23	2.8 × 10^3	5.9 × 10^3	0.67
TNF-α	1.2 × 10^7	1.1 × 10^7	1.00
TNF-α serum	0	0	0.58
TNF-β	5.9 × 10^3	6.0 × 10^3	1.00
Growth factors
BDNF	4.5 × 10^3	−1.9 × 10^2	0.03
GM-CSF	2.0 × 10^4	7.5 × 10^4	0.09
IL-3	9.4	0.8	0.40
SCF	5.7 × 10^5	2.4 × 10^5	0.09
VEGF	1.2 × 10^5	8.1 × 10^4	0.40
Matrix metalloproteinases
MMP-3	5.3 × 10^3	3.9 × 10^3	0.20
MMP-9	6.3 × 10^4	5.0 × 10^4	0.40
Acute phase protein
CRP	2.4 × 10^3	2.3 × 10^3	0.76

BDNF: brain-derived neurotrophic factor; CK: creatine kinase; CRP: C-reactive protein; GM-CSF: granulocyte macrophage colony-stimulating factor; ICAM-1: intercellular adhesion molecule 1; IFN-γ: interferon-gamma; LDH: lactate dehydrogenase; MMP: matrix metalloproteinase; SCF: stem cell factor; TNF: tumor necrosis factor; VEGF: vascular endothelial growth factor.