Mediators of Inflammation / 2016 / Article / Fig 2

Research Article

A Single Bout of Fasting (24 h) Reduces Basal Cytokine Expression and Minimally Impacts the Sterile Inflammatory Response in the White Adipose Tissue of Normal Weight F344 Rats

Figure 2

Effect of a 24 h fast on the TNF-α and IL-1β response to 10 or 100 acute inescapable tail shocks in WAT. Fed (FED □) or fasted (FASTED ■) rats were exposed to 0 (control condition), 10, or 100 acute, inescapable tail shocks (IS) and immediately sacrificed and subcutaneous, intraperitoneal, and visceral WAT were collected. Shown is the mean (+SEM) concentration of (a) tumor necrosis factor alpha (TNF-α); (0IS versus 10IS within WAT compartment), , (main effect of FED versus FASTED within WAT compartment), and (FED + 10IS versus FASTED + 10IS within WAT compartment); (b) interleukin- (IL-) 1 beta (IL-1β), (0IS versus 100IS within WAT compartment and fed condition) and (FED + 100IS versus FASTED + 100IS within WAT compartment); (c) interleukin- (IL-) 6, (0IS versus 100IS within WAT compartment); (d) IL-10, (0IS versus 10 or 100IS within WAT compartment), and (main effect of FED versus FASTED within WAT compartment).

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