Mediators of Inflammation / 2016 / Article / Tab 3

Research Article

Low-Dose Steroid Therapy Is Associated with Decreased IL-12 Production in PBMCs of Severe Septic Patients

Table 3

Cytokine responses (pg/mL, mean ± standard error mean) on days 1 and 7 in no-low-dose steroid, low-dose steroid, and control groups.

No-low-dose steroid
()
Low-dose steroid
()
All patients
()
Controls
()

Day 1
 IL-1182.0 ± 18.6200.0 ± 5.6193.1 ± 7.8110.8 ± 8.3
 IL-6375.0 ± 40.2416.2 ± 13.8400.6 ± 17.5385.4 ± 31.7
 IL-10340.4 ± 84.6333.1 ± 74.1335.8 ± 55.1305.5 ± 29.4
 IL-12514.1 ± 151.8141.3 ± 39.5282.7 ± 69.9266.6 ± 50.5
 IL-174.7 ± 4.32.6 ± 1.33.4 ± 1.81.0 ± 0.5
 TGF-126.3 ± 15.392.5 ± 28.767.4 ± 19.536.0 ± 9.9
 TNF-404.9 ± 39.5279.8 ± 41.2327.2 ± 31.4540.8 ± 34.4

Day 7
 IL-1189.8 ± 5.8191.7 ± 5.7191.9 ± 4.1
 IL-6356.4 ± 35.2410.3 ± 12.7389.9 ± 15.9
 IL-10339.3 ± 58.5237.4 ± 41.0276.0 ± 34.4
 IL-121145.7 ± 337.5269.5 ± 57.7601.9 ± 152.1
 IL-170.8 ± 0.44.6 ± 1.93.2 ± 1.2
 TGF-125.3 ± 16.228.2 ± 11.927.1 ± 9.4
 TNF-434.7 ± 14.3367.1 ± 24.5392.8 ± 17.1

IL = interleukin; TGF = transforming growth factor; and TNF = tumor necrosis factor.
compared to no-low-dose steroid group, by Mann-Whitney test.
compared to all patients with severe sepsis, by Mann-Whitney test.
compared within the same group on day 1, by Wilcoxon signed-rank test.

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