Low-Dose Steroid Therapy Is Associated with Decreased IL-12 Production in PBMCs of Severe Septic Patients

Table 4

Cytokine responses (pg/mL, mean ± standard error mean) on days 1 and 7 in survivors, nonsurvivors, and control groups.

	Survivors; ()	Nonsurvivors; ()	All patients; ()	Controls; ()
Day 1
IL-1	193.2 ± 9.2	192.9 ± 15.7	193.1 ± 7.8	110.8 ± 8.3
IL-6	407.0 ± 21.4	376.2 ± 19.5	400.6 ± 17.5	385.4 ± 31.7
IL-10	298.1 ± 59.4	480.5 ± 132.0	335.8 ± 55.1	305.5 ± 29.4
IL-12	325.8 ± 84.1	117.6 ± 77.0	282.7 ± 69.9	266.6 ± 50.5
IL-17	3.5 ± 2.2	2.8 ± 2.3	3.4 ± 1.8	1.0 ± 0.5
TGF-1	49.3 ± 17.8	136.8 ± 60.8	67.4 ± 19.5	36.0 ± 9.9
TNF-	348.6 ± 35.4	245.1 ± 61.8	327.2 ± 31.4	540.8 ± 34.4
Day 7
IL-1	192.0 ± 3.5	187.2 ± 15.6	191.9 ± 4.1
IL-6	394.1 ± 19.3^†	373.5 ± 21.8	389.9 ± 15.9^†
IL-10	273.5 ± 39.6	285.8 ± 74.7	276.0 ± 34.4
IL-12	696.0 ± 185.7^†	241.1 ± 108.2	601.9 ± 152.1^†
IL-17	2.7 ± 1.1	4.8 ± 4.6	3.2 ± 1.2
TGF-1	27.8 ± 10.7	24.5 ± 21.9	27.1 ± 9.4^†
TNF-	403.9 ± 15.2	349.9 ± 59.5	392.8 ± 17.1

IL = interleukin; TGF = transforming growth factor; and TNF = tumor necrosis factor.
compared to all patients with severe sepsis, by Mann-Whitney test.
compared within the same group on day 1, by Wilcoxon signed-rank test.