Mediators of Inflammation / 2016 / Article / Tab 4

Research Article

Low-Dose Steroid Therapy Is Associated with Decreased IL-12 Production in PBMCs of Severe Septic Patients

Table 4

Cytokine responses (pg/mL, mean ± standard error mean) on days 1 and 7 in survivors, nonsurvivors, and control groups.

Survivors
()
Nonsurvivors
()
All patients
()
Controls
()

Day 1
 IL-1193.2 ± 9.2192.9 ± 15.7193.1 ± 7.8110.8 ± 8.3
 IL-6407.0 ± 21.4376.2 ± 19.5400.6 ± 17.5385.4 ± 31.7
 IL-10298.1 ± 59.4480.5 ± 132.0335.8 ± 55.1305.5 ± 29.4
 IL-12325.8 ± 84.1117.6 ± 77.0282.7 ± 69.9266.6 ± 50.5
 IL-173.5 ± 2.22.8 ± 2.33.4 ± 1.81.0 ± 0.5
 TGF-149.3 ± 17.8136.8 ± 60.867.4 ± 19.536.0 ± 9.9
 TNF-348.6 ± 35.4245.1 ± 61.8327.2 ± 31.4540.8 ± 34.4

Day 7
 IL-1192.0 ± 3.5187.2 ± 15.6191.9 ± 4.1
 IL-6394.1 ± 19.3373.5 ± 21.8389.9 ± 15.9
 IL-10273.5 ± 39.6285.8 ± 74.7276.0 ± 34.4
 IL-12696.0 ± 185.7241.1 ± 108.2601.9 ± 152.1
 IL-172.7 ± 1.14.8 ± 4.63.2 ± 1.2
 TGF-127.8 ± 10.724.5 ± 21.927.1 ± 9.4
 TNF-403.9 ± 15.2349.9 ± 59.5392.8 ± 17.1

IL = interleukin; TGF = transforming growth factor; and TNF = tumor necrosis factor.
compared to all patients with severe sepsis, by Mann-Whitney test.
compared within the same group on day 1, by Wilcoxon signed-rank test.

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