Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid
Effect of AQCA on in vivo inflammatory symptoms. ((a)(A) and (b)(A)) Mice were treated with orally administered AQCA (0, 3, and 30 mg/kg) or ranitidine (40 mg/kg) for 3 days prior to oral administration of EtOH/HCl or aspirin (600 mg/kg). After 24 h, gastric lesions in the stomach were measured using a pixel counter ((a)(B) and (b)(B)), and photographs of these lesions were taken using a camera ((a)(A) and (b)(A)). ((b)(B)) MPO activity, indicative of neutrophil infiltration in the stomach, was determined in total lysates of stomach from aspirin-treated mice administered with AQCA. (c) Histological examination of aspirin-treated stomach was performed by H&E staining after parafilm-fixed section. and compared with the control group.