Epidermal Growth Factor and Intestinal Barrier Function

Table 1

The applications of EGF for animals on intestinal development.

Animal	Dose	Significant results	Reference
Fetal rabbit	300 µg/kg/d	EGF infusion significantly increased intrauterine growth retardation, fetal small intestinal villus height, and crypt cells	[35]
Early-weaned pigs	1.5 mg/kg	Increased the mucosa IgA levels and crypt depth at jejunum on day 28 after weaning	[36]
Early-weaned mice	50 µg/kg	Increased mean villous height and crypt depth and enhanced enterocyte proliferation	[37]
1-day-old, large white-duroc cross breed piglets	10 µg/kg/d	Stimulates proliferation of intestinal crypt epithelial cells and promotes recovery from atrophic enteritis in PEDV-infected piglets	[49]
Early-weaned pigs	1.0 mg/kg diet	Failed to alter the small intestinal villus morphology, DNA, or protein content of gastrointestinal mucosa	[19]
Early-weaned pigs	50 µg/kg BW/d	Greater jejunal and duodenal villus heights; greater intestinal length	[20]
Early-weaned pigs	180 µg/d	Increased villous height in the duodenum, jejunum, and ileum	[21]
Early-weaned pigs	115 µg/kg BW/d	Enhanced jejunal structure development, increased villi height, and decreased lamina propria width	[15]
Early-weaned pigs	180 µg/d	Increased villus height and increased the intestinal structural integrity proteins expression	[22]
Early-weaned pigs	60 µg/kg BW/d	Enhanced mean villous height, crypt depth, and villous height: crypt depth and stimulated proliferation of piglet enterocytes	[38]
Early-weaned rats	50 μg/kg	Enhanced mean villous height, crypt depth, total protein, DNA, and RNA and stimulated enterocytes proliferation	[39]