Table 1: The applications of EGF for animals on intestinal development.

Animal DoseSignificant resultsReference

Fetal rabbit300 µg/kg/dEGF infusion significantly increased intrauterine growth retardation, fetal small intestinal villus height, and crypt cells[35]
Early-weaned pigs1.5 mg/kgIncreased the mucosa IgA levels and crypt depth at jejunum on day 28 after weaning[36]
Early-weaned mice50 µg/kgIncreased mean villous height and crypt depth and enhanced enterocyte proliferation [37]
1-day-old, large white-duroc cross breed piglets10µg/kg/dStimulates proliferation of intestinal crypt epithelial cells and promotes recovery from atrophic enteritis in PEDV-infected piglets[49]
Early-weaned pigs1.0mg/kg dietFailed to alter the small intestinal villus morphology, DNA, or protein content of gastrointestinal mucosa[19]
Early-weaned pigs50µg/kgBW/dGreater jejunal and duodenal villus heights; greater intestinal length [20]
Early-weaned pigs180µg/dIncreased villous height in the duodenum, jejunum, and ileum[21]
Early-weaned pigs115µg/kgBW/dEnhanced jejunal structure development, increased villi height, and decreased lamina propria width[15]
Early-weaned pigs180µg/dIncreased villus height and increased the intestinal structural integrity proteins expression [22]
Early-weaned pigs60µg/kgBW/dEnhanced mean villous height, crypt depth, and villous height: crypt depth and stimulated proliferation of piglet enterocytes[38]
Early-weaned rats50μg/kgEnhanced mean villous height, crypt depth, total protein, DNA, and RNA and stimulated enterocytes proliferation[39]