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Mediators of Inflammation
Volume 2016, Article ID 2042107, 10 pages
http://dx.doi.org/10.1155/2016/2042107
Research Article

Effects of Anthocyanin and Flavanol Compounds on Lipid Metabolism and Adipose Tissue Associated Systemic Inflammation in Diet-Induced Obesity

1Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, Netherlands
2Top Institute Food and Nutrition, 6709 AN Wageningen, Netherlands
3Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), 2333 CK Leiden, Netherlands
4Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, Netherlands
5Department of Pediatrics, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, Netherlands
6Avans University of Applied Sciences, 5223 DE Breda, Netherlands
7Molecular Genetics, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, Netherlands
8Department of Internal Medicine, Maastricht University Medical Centre, Maastricht University, 6229 HX Maastricht, Netherlands

Received 18 March 2016; Accepted 5 May 2016

Academic Editor: Bing Du

Copyright © 2016 Roel A. van der Heijden et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary material shows schematic representation of the study's design and the analyses that were performed (Suppl. Fig. 1). Furthermore the average caloric intake per day as measured over seven days is shown for three time points and depicts that similar caloric intake was observed in HFD, HFD+E and HFD+B groups (Suppl. Fig. 2). Other inflammatory markers that were assessed but did not show any significant differences between the diets are shown. Serial plasma levels of IL-6, IFN-y, IL-10 and SAA show not to be affected by HFD-feeding or by polyphenol supplementation (Suppl. Fig. 3). Lastly, hepatic triglyceride profile at sacrifice is shown. In-depth analysis of hepatic liver lysates shows no significant effect of polyphenol supplementation on any of the fatty acid groups assessed (Suppl. Table 1).

  1. Supplementary Material